Cellectis Presents Preclinical Data Highlighting Efficient APOC3 Editing and Marked Triglyceride Reduction with .HEAL-101 at ESGCT 2026

  • 70% in vivo editing of human APOC3 in a single administration

  • 76% triglyceride reduction after a single dose in murine disease model

NEW YORK, Oct. 27, 2026 (GLOBE NEWSWIRE) — Cellectis (Euronext Growth: ALCLS – Nasdaq: CLLS), a genome engineering company developing genetic medicines for diseases that today demand a lifetime of treatment, today announced the presentation of preclinical data supporting .HEAL-101, its in vivo base editing product candidate targeting APOC3 for severe hypertriglyceridemia (sHTG), at the Annual Congress of the European Society of Gene and Cell Therapy (ESGCT), being held October 27-30, 2026, in Hamburg, Germany.

.HEAL-101 is an APOC3-specific TALE base editor delivered as mRNA in liver-directed lipid nanoparticles (LNPs), designed to permanently inactivate APOC3, a genetically validated driver of elevated triglycerides, after a single intravenous administration. The poster presents an expanded preclinical data set for .HEAL-101, building on the initial dataset first disclosed by Cellectis on September 14, 2026.

“These expanded preclinical data reinforce the potential of our TALE base editing approach to achieve efficient and specific APOC3 editing following a single administration,” said Julien Valton, Ph.D., Vice President, Gene Therapy at Cellectis. “The substantial reduction in triglyceride level observed across our preclinical study provide further support for the development of .HEAL-101 as a potential one-time treatment for patients with severe hypertriglyceridemia.”

Key findings presented at ESGCT

  • Efficient and highly specific editing of APOC3

    in vitro

    : In a human hepatic cell line, .HEAL-101 achieved a mean APOC3 editing rate of approximately 90%, without production of DNA double strand break at the target site.
  • Efficient editing of human APOC3

    in vivo

    : In a normolipidemic humanized liver mouse model, a single intravenous injection of LNP-mRNA edited the human APOC3 gene at a mean rate of approximately 65%, reaching up to 70%.
  • Marked efficacy in a disease model: In a hyper triglyceridemic human APOC3 transgenic mouse model of hypertriglyceridemia, .HEAL-101 reduced APOC3 by 67% ± 12%, and triglycerides by 75% ± 11% (mean ± standard deviation).
  • Liver-restricted activity: Editing was detected in the liver, with no significant activity in the other tissues analyzed.

These preclinical results support the continued development of .HEAL-101. Cellectis plans to initiate a Phase 1 investigator-initiated trial (IIT) in China with preliminary clinical data expected in the second half of 2027.

Poster Information:

Title:
In vivo editing of human APOC3 by TALE base editor normalizes triglyceride levels in animal models

Presenter: Julien Valton, Ph.D., Vice President Gene Therapy at Cellectis

Presentation date/time: Thursday, October 29 from 2 to 4 p.m. CET.

Poster number: P0208

The poster presentation is now available on Cellectis’ website.

About Cellectis

Cellectis is a genome engineering company developing genetic medicines for diseases that today demand a lifetime of treatment. Leveraging decades of expertise in programmable DNA-binding proteins, the Company has built a differentiated genome engineering platform spanning gene editing, base editing, epigenetic editing and transcriptional regulation. By delivering the genomic intervention each disease requires, Cellectis is advancing a new generation of genetic medicines designed to move beyond disease management and toward lasting therapeutic impact. Cellectis’ headquarters are in Paris, France, with locations in New York and Raleigh (NC). Cellectis is listed on the Nasdaq Global Market (ticker: CLLS) and on Euronext Growth (ticker:ALCLS). To find out more, visit www.cellectis.com and follow Cellectis on LinkedIn and X.

Cautionary Statement

This press release contains “forward-looking” statements within the meaning of applicable securities laws, including the Private Securities Litigation Reform Act of 1995. Forward-looking statements may be identified by words such as “designed to” , “expected” , “plan”, “potential”, or similar expressions and/or the negative of these. These forward-looking statements are based on our management’s current expectations and assumptions and on information currently available to management. Forward-looking statements in this press release include statements regarding the ability of the Company to initiate a IIT in China, the planned timing for the release of preliminary clinical data for the Company’s lead program, the potential of the Company’s preclinical candidate product based on pre-clinical results, the potential for success of the Company’s in vivo gene editing programs. Actual results, performance or events may differ materially from those projected in any forward-looking statement. Many important factors may adversely affect such forward-looking statements and cause actual results to differ from those in any forward-looking statement, including, without limitation, uncertainties inherent in the initiation and completion of preclinical and clinical studies; the availability and timing of results from studies, once initiated; the acceptance by global regulatory agencies of data generated from IIT in China; the potential that pre-clinical animal model data may not translate into further preclinical development or clinical setting; promising preclinical data not yielding positive further preclinical data or clinical results; the performance of the IIT in China, changes in the competitive landscape for in vivo gene editing products; expectations for regulatory approvals to conduct clinical trials; Furthermore, many other important factors, including those described in our Annual Report on Form 20-F as amended and in our annual financial report (including the management report) for the year ended December 31, 2025 and subsequent filings Cellectis makes with the Securities Exchange Commission from time to time, which are available on the SEC’s website at www.sec.gov, as well as other known and unknown risks and uncertainties may adversely affect such forward-looking statements and cause our actual results, performance or achievements to be materially different from those expressed or implied by the forward-looking statements. Except as required by law, we assume no obligation to update these forward-looking statements publicly, or to update the reasons why actual results could differ materially from those anticipated in the forward-looking statements, even if new information becomes available in the future.

For further information on Cellectis, please contact:

Media contacts:

Pascalyne Wilson, Director, Communications, + 33 (0)7 76 99 14 33, [email protected]
Patricia Sosa Navarro, Chief of Staff to the CEO, +33 (0)7 76 77 46 93

Investor Relations contact:

Arthur Stril, Chief Financial Officer & Chief Business Officer, [email protected]

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Sea Limited to Report Third Quarter 2026 Results

Sea Limited to Report Third Quarter 2026 Results

SINGAPORE–(BUSINESS WIRE)–
Sea Limited (NYSE: SE) (“Sea” or the “Company”) plans to announce its third quarter 2026 results before the U.S. market opens on November 10, 2026, U.S. Eastern Time.

The Company’s management will host a conference call to discuss the third quarter 2026 results. A live webcast of this conference call will be available on the Company’s website.

Details of the webcast are as follows:

Date and time:

7:30 AM U.S. Eastern Time on November 10, 2026

8:30 PM Singapore / Hong Kong Time on November 10, 2026

 

Webcast link:

https://events.q4inc.com/attendee/360627099

 

A replay of the conference call will be available at the Company’s investor relations website (www.sea.com/investor/home). An archived webcast will be available at the same link above.

About Sea

Sea Limited (NYSE: SE) is a global technology company founded in Singapore in 2009. Its mission is to better the lives of consumers and small businesses with technology. Sea operates three core businesses across e-commerce, digital financial services, and digital entertainment, known as Shopee, Monee, and Garena respectively. Shopee is the largest e-commerce platform in Southeast Asia and Taiwan and is a leading e-commerce platform in Brazil. Monee is a leading digital financial services provider in Southeast Asia with a growing presence in Latin America. Garena is a leading global online games developer and publisher.

For more information, visit www.sea.com.

For enquiries, please contact:

Investors / analysts: [email protected]

Media: [email protected]

KEYWORDS: Singapore Southeast Asia Asia Pacific

INDUSTRY KEYWORDS: Retail Online Mobile Entertainment Technology Finance Fintech Small Business Banking Professional Services Online Retail Electronic Commerce Digital Cash Management/Digital Assets Electronic Games Software Entertainment Internet

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CoreWeave Expands Global AI Cloud Platform With New Capacity in Denmark and First Global AI Network Backbone

CoreWeave Expands Global AI Cloud Platform With New Capacity in Denmark and First Global AI Network Backbone

Expansion brings additional AI computing capacity online in Europe and extends CoreWeave’s high-performance global network to support customers building and scaling AI worldwide

LONDON–(BUSINESS WIRE)–CoreWeave, Inc. (Nasdaq: CRWV), The Essential Cloud for AI™, today announced an expansion of its global AI cloud platform, bringing new computing capacity online in Denmark and extending its Global AI Network into the Middle East and Asia Pacific. The expansion strengthens CoreWeave’s ability to deliver the performance, reliability, and connectivity customers need to build and scale AI workloads across international markets.

As AI workloads move into production across more industries and geographies, customers need computing capacity where they operate and the ability to move large volumes of data securely and efficiently between regions. CoreWeave is expanding both capabilities as part of its fully integrated, purpose-built AI cloud platform, reducing the infrastructure complexity that can slow AI development and deployment.

With this expansion, CoreWeave is building the first global AI backbone network, purpose-built for AI workloads, at Petabit-scale, that connects locations in North America, Europe, the Middle East, and Asia Pacific.

“Our customers need more than access to computing capacity. They need infrastructure that performs reliably at scale and the ability to move data and workloads wherever their business requires,” said Sachin Jain, chief operating officer of CoreWeave. “We’re expanding our global infrastructure and the network connecting it together, so customers can focus on building and improving AI rather than managing the complexity underneath it.”

CoreWeave has brought the majority of its planned 22.5 megawatts (MW) of IT capacity online at atNorth’s DEN01 data center in Copenhagen, marking its first deployment in Denmark. DEN01 has a heat reuse agreement in place to supply surplus heat to the district heating network, reducing reliance on alternative heating sources and contributing to Denmark’s green transition.

Accelerated by NVIDIA Blackwell systems connected with NVIDIA Quantum-X800 InfiniBand, the facility expands CoreWeave’s European infrastructure footprint to nine data centers across five geographies, including the United Kingdom, Spain, Sweden, and Norway.

“Modern workloads demand digital infrastructure that is not only high performance, but also energy efficient and responsibly operated, “said Eyjólfur Magnús Kristinsson, CEO at atNorth. “By partnering with atNorth, CoreWeave gains access to DEN01’s infrastructure, designed for GPU-intensive processing, while supporting renewable energy development through power purchase agreements and helping warm local homes through heat reuse, contributing to the green transition.”

To connect its growing international infrastructure footprint, CoreWeave is extending its global AI network backbone with new points of presence in the United Arab Emirates, India, Indonesia, Singapore, Australia, Korea and Japan, beginning later in the fourth quarter of 2026 and extending to a full loop in mid-2027. The expansion will extend CoreWeave’s existing network across North America and Europe into four continents, providing customers with more direct connectivity to its AI cloud platform.

Purpose-built for AI workloads, CoreWeave’s backbone combines multiple 400 gigabit-per-second connections at each point of presence, hardware-based MACsec encryption to protect data in transit, and redundant network paths designed to maintain performance and reliability across regions. Together, these capabilities enable customers to move large datasets and access computing infrastructure without sacrificing the speed or security their workloads require.

The expansion follows CoreWeave’s recent announcements in Indonesia and India, reflecting continued investment in the infrastructure needed to support AI development and deployment globally. CoreWeave operated 51 data centers worldwide with more than 1.5 gigawatts of active power as of June 30, 2026 and had approximately 4.2 gigawatts of contracted power as of its August 11, 2026 earnings call.

CoreWeave consistently delivers industry-leading performance, demonstrated by record-breaking MLPerf benchmark results in inference and training and its position as the only AI cloud to earn the top Platinum ranking in SemiAnalysis ClusterMAX™ three times in a row.

About CoreWeave

CoreWeave is The Essential Cloud for AI®. Built for pioneers by pioneers, CoreWeave delivers a fully integrated platform of technology and teams that enables innovators to move at the pace of innovation, building and scaling AI with confidence. Trusted by 9 of the 10 leading foundation model providers, CoreWeave serves as a force multiplier by combining superior infrastructure performance with deep technical expertise to accelerate human discovery. Established in 2017, CoreWeave completed its public listing on Nasdaq (CRWV) in March 2025.

About atNorth

atNorth is a leading Nordic data center company that offers cost-effective, scalable high-density colocation and built-to-suit services trusted by industry-leading organizations.

With sustainability at its core, atNorth’s data centers run on renewable energy resources and support circular economy principles. All atNorth sites leverage innovative design, power efficiency, and intelligent operations to provide long-term infrastructure and flexible colocation deployments.

atNorth is headquartered in Reykjavik, Iceland and operates seven data centers in strategic locations across the Nordics, as well four mega sites under development across Kouvola Finland, Ølgod, Denmark, Sollefteå, Sweden and Haugaland, Norway. The business also has an additional metro site under construction in Stockholm, Sweden.

For more information, visit atNorth.com or follow atNorth on LinkedIn.

[email protected]

KEYWORDS: North America United States United Kingdom Europe Denmark

INDUSTRY KEYWORDS: Hardware Alternative Energy Security Data Management Energy Green Technology Sustainability Technology Apps/Applications Environment Artificial Intelligence Software Networks Other Energy Internet

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Informa TechTarget: Nine-Month Revenue Update

Informa TechTarget: Nine-Month Revenue Update

NEWTON, Mass.–(BUSINESS WIRE)–
TechTarget, Inc. (Nasdaq: TTGT) (“Informa TechTarget” or the “Company”), an indispensable partner for B2B intelligence, media and marketing solutions, today provides a brief update ahead of Informa PLC’s (“Informa”, the majority shareholder in TTGT) trading update which will include information on Informa TechTarget.

For the nine-month period to September 30, 2026, Informa will report underlying revenue growth for Informa TechTarget of -1.6% versus the comparable prior year period reflecting continuing market volatility, with enterprise technology customers prioritizing AI investment over product marketing and sales support.

As previously announced, Informa TechTarget will release its own full results for the quarter and nine-month periods to September 30, 2026 under US GAAP on November 6, 2026 which will be followed by a conference call with company management.

About Informa TechTarget

Informa TechTarget informs, influences and connects the world’s technology buyers and sellers, and aims to be an indispensable partner in driving clients’ go-to-market success. With a vast reach of over 220 highly targeted technology-specific digital properties and approximately 58 million permissioned first-party audience members, Informa TechTarget has a unique understanding of and insight into the technology market.

As a leading provider of market intelligence, industry journalism, brand and demand marketing solutions, content strategy and creation, and exclusive buyer intent data, we deliver expert-led, data-driven, and digitally enabled services that create significant impact and measurable outcomes for our clients. All of this is underpinned by a unique audience data ecosystem and fueled by buyer insights and expertise.

Informa TechTarget is headquartered in Boston, MA and has offices in 19 global locations. For more information, visit informatechtarget.com and follow us on LinkedIn.

© 2026 TechTarget, Inc. d/b/a Informa TechTarget. All rights reserved. All trademarks are the property of their respective owners.

Cautionary Note Regarding Forward-Looking Statements

This press release contains “forward-looking statements”. All statements, other than historical facts, are forward-looking statements, including: statements regarding the expected benefits of the transactions consummated on December 2, 2024 (the “Closing Date”) pursuant to the Agreement and Plan of Merger, dated as of January 10, 2024, among TechTarget Holdings Inc. (formerly known as TechTarget, Inc. (“Former TechTarget”)), Informa TechTarget, Toro Acquisition Sub, LLC, Informa PLC, Informa US Holdings Limited, and Informa Intrepid Holdings Inc. (the “Transactions”), such as improved operations, enhanced revenues and cash flow, synergies, growth potential, market profile, business plans, expanded portfolio and financial strength; our expectations surrounding the Transactions and our ability to grow our business and bolster our financial position; our expected contractual obligations and capital expenditures; our future results of operations and financial position; industry and business trends; the impact of market conditions and other macroeconomic factors on our business, financial condition and results of operations and guidance for 2026; our future business strategy, plans, market growth and our objectives for future operations; the effectiveness of our restructuring and workforce reduction program; the continued remediation of material weaknesses in our internal control over financial reporting; and our competitive market position within our industry. Forward-looking statements concern future circumstances and results and other statements that are not historical facts and are sometimes identified by the words “may,” “will,” “should,” “potential,” “intend,” “expect,” “endeavor,” “seek,” “anticipate,” “estimate,” “overestimate,” “underestimate,” “believe,” “plan,” “could,” “would,” “project,” “predict,” “continue,” “target,” or the negatives of these words or other similar terms or expressions that concern Informa TechTarget’s expectations, strategy, priorities, plans, or intentions. Forward-looking statements are based upon current plans, estimates, and expectations that are subject to risks, uncertainties, and assumptions. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those indicated or anticipated by such forward-looking statements. We can give no assurance that such plans, estimates, or expectations will be achieved, and therefore, actual results may differ materially from any plans, estimates, or expectations in such forward-looking statements.

Important factors that could cause actual results to differ materially from such plans, estimates, or expectations include, among others: unexpected costs, charges, or expenses resulting from the Transactions; uncertainty regarding the expected financial performance of Informa TechTarget; failure to realize the anticipated benefits of the Transactions, including as a result of integrating the Informa Tech Digital Businesses with the business of Former TechTarget; the ability of Informa TechTarget to implement its business strategy; difficulties and delays in Informa TechTarget achieving revenue and cost synergies; evolving legal, regulatory, and tax regimes; changes in economic, financial, political, and regulatory conditions, in the United States and elsewhere, and other factors that contribute to uncertainty and volatility such as inflationary pressures and geopolitical tensions including war; natural and man-made disasters, civil unrest, pandemics, geopolitical uncertainty and conflicts, and conditions that may result from legislative, regulatory, trade, and policy changes associated with the current or subsequent U.S. administrations; Informa TechTarget’s ability to meet expectations regarding the accounting and tax treatments of the Transactions; market acceptance of Informa TechTarget’s products and services; the impact of pandemics and future health epidemics and any related economic downturns on Informa TechTarget and the markets in which it and its customers operate; changes in economic or regulatory conditions or other trends affecting the internet, internet advertising and information technology industries; data privacy and artificial intelligence laws, rules, and regulations; the impact of foreign currency exchange rates; certain macroeconomic factors facing the global economy, including disruptions in the capital markets, economic sanctions and economic slowdowns or recessions, tariffs and trade disputes, rising inflation and interest rate fluctuations on the operating results of Informa TechTarget; and other matters included in Risk Factors of Informa TechTarget’s Form 10-K for fiscal year 2025 (filed with the United States Securities and Exchange Commission (the “SEC”) on March 11, 2026) and other documents filed by Informa TechTarget from time to time with the SEC. This summary of risks and uncertainties should not be considered to be a complete statement of all potential risks and uncertainties that may affect Informa TechTarget. Other factors may affect the accuracy and reliability of forward-looking statements. We caution you not to place undue reliance on any of these forward-looking statements as they are not guarantees of future performance or outcomes. Actual performance and outcomes, including, without limitation, Informa TechTarget’s actual results of operations, financial condition and liquidity, may differ materially from those made in or suggested by the forward-looking statements contained in this press release.

Any forward-looking statements speak only as of the date of this press release. None of Informa TechTarget, its affiliates, advisors or representatives, undertake any obligation to update any forward-looking statements, whether as a result of new information or developments, future events, or otherwise, except as required by applicable law. Readers are cautioned not to place undue reliance on any of these forward-looking statements.

Investor Inquiries

Daniel Noreck

Chief Finance Officer

Informa TechTarget

[email protected]

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Garrett Mann

Corporate Communications

Informa TechTarget

[email protected]

KEYWORDS: Massachusetts United States North America

INDUSTRY KEYWORDS: Technology Business Consulting Professional Services Publishing Other Technology Marketing Software Digital Marketing Advertising Data Analytics Communications Internet Data Management

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Publication of the Q3 2026 financial results on Tuesday, November 3, 2026, after market close

Paris, France – October 27, 2026

Q3 2026 financial results and conference call

Viridien will publish its third quarter 2026 results on Tuesday, November 3, after market close.

  • The press release and presentation will be made available on www.viridiengroup.com at 5.45 pm (CET)
  • An English-language conference call is scheduled at 6.00 pm (CET) on the same day

Participants must register for the conference call by clicking here to receive a dial-in number and PIN code. Participants may also join the live webcast by clicking here.

A replay of the conference call will also be available, for a period of 12 months, on the Company’s website www.viridiengroup.com.

About Viridien:

Viridien (www.viridiengroup.com) is an advanced technology, digital and Earth data company that pushes the boundaries of science for a more prosperous and sustainable future. With our ingenuity, drive and deep curiosity we discover new insights, innovations, and solutions that efficiently and responsibly resolve complex natural resource, digital, energy transition and infrastructure challenges. Viridien employs around 3,000 people worldwide and is listed as VIRI on the Euronext Paris SA (ISIN: FR001400PVN6).

Contacts

Investor Relations

Alexandre Leroy
Tel: + 33 6 85 18 44 31
E-Mail: [email protected]
Media Relations

Sara Pink-Zerling
Tel: + 33 6 37 57 95 44
E-Mail: [email protected]

Attachment



Pharming Group reports third quarter 2026 financial results; strong revenue growth, Joenja APDS expansion and CVID topline data in November

  • Third quarter 2026 total revenues increased by 21% to US$117.6 million, compared to third quarter 2025, exceeding market expectations
  • RUCONEST® revenue increased by 14% to US$93.8 million, compared to third quarter 2025, reflecting demand stabilization and seasonal inventory increase
  • Joenja® (leniolisib) revenue increased by 58% to US$23.8 million, compared to third quarter 2025, reflecting strong U.S. and international demand
  • Tightened 2026 total revenue guidance to US$380 million – US$390 million from prior US$375 million – US$395 million
  • Operating profit increased by 89% to US$29.9 million, compared to third quarter 2025
  • Generated US$32.4 million in cash flow from operations in the quarter and US$24.7 million year to date, increasing cash position to US$190.9 million
  • Strong progress on Joenja expansion including U.S. pediatric label and launches in Germany and Japan
  • Announced positive Phase II topline data for leniolisib in genetic PIDs with immune dysregulation and Phase II topline data in broader CVID patient population expected in November 2026
  • Pharming to host a conference call today at 13:30 CET (8:30 am EDT)

Leiden, the Netherlands, October 27, 2026: Pharming Group N.V. (Euronext Amsterdam: PHARM/Nasdaq: PHAR), a global biotechnology company focused on rare immune and genetic diseases, presents its preliminary (unaudited) financial report for the three months ended September 30, 2026.

Interim Co-Chief Executive Officer Kenneth Lynard commented: “This was a quarter of execution and delivery for Pharming. We set three near-term goals – stabilizing and returning RUCONEST to revenue growth, expanding Joenja (leniolisib)’s reach, and generating Phase II data for leniolisib beyond APDS. We made strong progress on all three in the third quarter, and momentum continues into the fourth quarter. RUCONEST quarterly revenue rose 14% year-over-year to $93.8 million, supported by stabilized U.S. demand with the strongest retention in the high-burden patient segment, and continued new patient and prescribers additions. Joenja revenue grew 58% to $23.8 million with launches in Germany and Japan, higher U.S. uptake, and approval in the U.S. of new doses for children aged 4 to 11 above 27 kg with shipments commencing after quarter end. That performance translated into 21% revenue growth exceeding market expectations, an 89% increase in operating profit, and strong operating cash flow, highlighting our flexibility to invest in our priorities while staying disciplined on capital allocation.

Interim Co-Chief Executive Officer Leverne Marsh added: We are particularly encouraged by the recent positive Phase II results for leniolisib in genetically identifiable primary immunodeficiencies, which support the role of the PI3Kδ pathway in driving immune dysregulation beyond APDS. We look forward to reporting additional data in CVID in November. Together, results from both trials will inform the path toward a potential registrational study in the broader and larger CVID population. If supported by the data, this could represent a significant opportunity for leniolisib, building on the commercial capabilities we have established with Joenja to reach more patients and realize our long-term growth ambition.”

Third quarter highlights

Commercialized assets

RUCONEST marketed for the treatment of acute HAE attacks

RUCONEST revenue in the third quarter of 2026 was US$93.8 million, a 14% increase compared to the third quarter of 2025 and a 30% increase compared to the second quarter of 2026. Revenue for the first nine months of 2026 was US$224.5 million, a 3% decrease compared to the same period in 2025.

RUCONEST revenue in the current quarter compared to the third quarter of 2025 reflects stabilization and continued recovery of U.S. market demand, early seasonal increase in channel inventory at a single U.S. specialty pharmacy customer following significant drawdowns earlier in the year, and the completion of the planned withdrawal from non-U.S. markets.

The overwhelming majority of RUCONEST patients remain on therapy with the active patient base over 90% of year ago levels, with strongest retention in the high-burden patient segment. We continued to add new patients and prescribers, highlighting RUCONEST’s durable market position in high-burden HAE.

Joenja (leniolisib) marketed for the treatment of APDS

Joenja revenue increased to US$23.8 million in the third quarter of 2026, a 58% increase compared to the third quarter of 2025. Revenue for the first nine months of 2026 was US$55.7 million, a 45% increase compared to the same period in 2025.

Year-over-year revenue growth in the current quarter was driven by continued strong growth in the number of U.S. patients on paid therapy, significantly increased international demand – including from launches in Germany and Japan during the quarter and continued penetration in the U.K. – with temporary benefit from ordering patterns in other international markets.

The U.S. market contributed 67% of third quarter revenue, while international contributed 33%.

As of September 30, 2026, 136 patients were on paid therapy in the U.S., representing a 17% increase from the 116 patients at the end of the third quarter of 2025 and an increase of 4 patients during the quarter. Shipments of newly approved Joenja doses for children aged 4 to 11 years in the U.S. commenced in October, following the end of the quarter.

As of September 30, 2026, 75 patients were on paid therapy in international markets – 30 in launch markets and 45 on paid access programs in other international markets.

APDS patient finding

As of September 30, 2026, we have identified 1,056 diagnosed activated PI3Kδ syndrome (APDS) patients of all ages globally, including 304 patients in the U.S. and 390 in core markets outside of the U.S.

Joenja (leniolisib) development

Leniolisib for APDS

As of September 30, 2026, there are 136 APDS patients in either a leniolisib Expanded Access Program (compassionate use) or an ongoing clinical study.

Pediatric label expansion

On September 11, 2026, we announced that the U.S. Food and Drug Administration (FDA) had approved our supplemental New Drug Application (sNDA) for 40 mg and 50 mg twice-daily dosing of Joenja as a treatment for children aged 4 to 11 years weighing at least 27 kg with APDS.

On July 30, 2026, we submitted a separate sNDA seeking approval of lower Joenja doses for pediatric APDS patients aged 4 to 11 years who weigh 13 kg to 27 kg. On September 28, 2026, we announced that the FDA had accepted this sNDA and granted the application Priority Review and assigned a Prescription Drug User Fee Act (PDUFA) target action date of January 30, 2027.

Japan

On August 13, 2026, we announced the commercial launch of Joenja (leniolisib) in Japan for adult and pediatric patients with APDS aged 4 years and older, following its inclusion on the Japan National Health Insurance (NHI) drug price list. With this launch, Japan became the first market where Joenja was commercially available for children aged 4 to 11.

Leniolisib for additional primary immunodeficiencies (PIDs)

Two Phase II clinical trials are evaluating leniolisib for additional primary immunodeficiencies (PIDs) with immune dysregulation, including genetically identifiable PIDs linked to altered PI3Kδ signaling and common variable immunodeficiency (CVID), which represent substantially larger patient populations than APDS. The PI3Kδ pathway is seen as a key driver of immune dysregulation in many PIDs, and we are working towards a single registrational Phase III trial in the broader CVID indication, incorporating patient populations from both studies.

On October 14, 2026, we presented positive topline data from our Phase II trial of leniolisib in genetically identifiable PIDs with immune dysregulation at the 22nd Biennial Meeting of the European Society for Immunodeficiencies (ESID). This is the first clinical data for leniolisib in broader PIDs beyond APDS, supporting the potential of targeted PI3Kδ inhibition to address immune dysregulation. The trial enrolled 13 participants, nine of whom also had a CVID diagnosis. All participants who completed the study elected to continue receiving treatment in a long-term extension study.

The presentation highlighted leniolisib’s favorable safety and tolerability profile, as well as clinical improvements across measures of immune dysregulation. Clinical results included improvements in lymphoproliferative disease, with mean 26.4% spleen volume reduction (SVR) including reductions in nearly all evaluable participants, and reductions in the size of index lesions. Positive trends in lung and liver disease markers were also particularly noteworthy. The safety observations were consistent with the known safety profile of leniolisib, with infections as the most common events observed in study subjects, and no new safety signals identified. Notably, all 12 participants who completed the study elected to enroll in the three-year extension study.

Pharming expects to report Phase II results for leniolisib in CVID patients with immune dysregulation, with or without an identified genetic cause, in November 2026.

The estimated prevalence rate is approximately 7.5 patients per million for genetically identifiable PIDs and approximately 39 patients per million for CVID with immune dysregulation, including overlap between the genetic PID and CVID populations, which are substantially larger than the approximately 1.5 patients per million for APDS.

Napazimone (KL1333) for mitochondrial DNA-driven primary mitochondrial disease

Napazimone (KL1333) is being evaluated in the pivotal FALCON clinical trial in adult patients with mtDNA-driven mitochondrial disease, and has the potential to become the first standard of care in this setting.

Over 50 clinical sites in the trial are actively recruiting, with significant expansion achieved in the U.S. We expect approximately 145 of the planned 180 subjects to be enrolled in FALCON by the end of 2026. We now expect enrollment to be completed in the first half of 2027. Topline results from the pivotal FALCON study are expected approximately one year after the completion of enrollment.

Organizational updates

On September 29, 2026, we announced that the Board of Directors and Fabrice Chouraqui had mutually agreed that Mr. Chouraqui would step down as Chief Executive Officer and Executive Director, with immediate effect. To ensure continuity of leadership, the Board of Directors appointed Mrs. Leverne Marsh, Chief Commercial Officer, and Mr. Kenneth Lynard, Chief Financial Officer, as Interim Co-CEOs.

Pharming’s strategy, pipeline and commitment to patients remain unchanged. Focus remains on executing the strategic priorities and advancing the next phase of growth.
Financial Summary

Consolidated Statement of Income 3Q 2026 3Q 2025 9M 2026 9M 2025
Amounts in US$m except per share data        
Total Revenues 117.6 97.3 280.2 269.6
Cost of sales (15.4) (7.1) (36.6) (24.4)
Gross profit 102.2 90.2 243.7 245.2
Other income 2.3 0.1 4.1 2.3
Research and development (29.6) (23.4) (87.4) (68.2)
General and administrative (15.6) (17.0) (45.7) (59.9)
Marketing and sales (29.5) (34.1) (88.3) (99.7)
Other Operating Costs (74.6) (74.5) (221.5) (227.9)
Operating profit (loss) 29.9 15.8 26.3 19.6
Finance result (net) and share of result in associates 1.4 (3.1) 3.2 (11.6)
Profit (loss) before tax 31.2 12.7 29.5 8.0
Income tax credit (expense) (8.8) (5.2) (10.7) (10.8)
Profit (loss) for the period 22.4 7.5 18.9 (2.8)
Earnings per share        
Basic, attributable to equity holders of the parent (US$) 0.032 0.011 0.027 (0.004)
Diluted, attributable to equity holders of the parent (US$) 0.030 0.010 0.025 (0.004)

Segment information – Revenues 3Q 2026 3Q 2025 9M 2026 9M 2025
Amounts in US$m        
Revenue – RUCONEST (US) 94.0 81.1 224.2 227.4
Revenue – RUCONEST (EU and RoW) (0.1) 1.1 0.3 3.9
Total Revenues – RUCONEST 93.8 82.2 224.5 231.2
Revenue – Joenja (US) 15.9 13.4 42.8 34.6
Revenue – Joenja (EU and RoW) 7.9 1.7 12.9 3.7
Total Revenues – Joenja 23.8 15.1 55.7 38.4
         
Total Revenues – US 109.8 94.5 267.0 262.0
Total Revenues – EU and RoW 7.7 2.7 13.2 7.6
         
Total Revenues 117.6 97.3 280.2 269.6

Consolidated Balance Sheet September 30, 2026 December 31, 2025
Amounts in US$m    
Cash and cash equivalents, restricted cash and marketable securities 190.9 181.1
Current assets 322.4 299.5
Total assets 496.6 500.0
Current liabilities 100.0 115.8
Shareholders’ equity 291.2 277.1

Figures may not add up due to rounding.

Financial highlights

Third quarter 2026

For the third quarter of 2026, total revenues increased by US$20.3 million, or 21%, to US$117.6 million, compared to US$97.3 million in the third quarter of 2025. RUCONEST revenues amounted to US$93.8 million, a 14% increase compared to the third quarter of 2025. This increase in RUCONEST revenues was primarily driven by a volume increase in the U.S. Joenja revenues amounted to US$23.8 million in the third quarter of 2026, a 58% increase compared to the third quarter of 2025. This increase in Joenja revenues was primarily driven by an increase in volume.

Gross profit increased by US$12.0 million or 13%, to US$102.2 million, compared to US$90.2 million in the third quarter of 2025, mainly due to the increase in revenues and partially offset by manufacturing-related impairments of inventory (US$5.1 million).

The operating profit increased 89% and amounted to US$29.9 million compared to US$15.8 million in the third quarter of 2025. Excluding US$5.1 million in one-time manufacturing-related impairments of inventory, adjusted operating profit1 in the third quarter 2026 amounted to US$35.0 million. Excluding US$0.2 million of non-recurring Abliva acquisition-related expenses, adjusted operating profit in the third quarter 2025 amounted to US$16.0 million. The improved operating result was primarily driven by an increase in revenues and other income from government grants supporting research and development activities.

The finance result (net) and share of result in associates amounted to a gain of US$1.4 million compared to a loss of US$3.1 million in the third quarter of 2025. This improvement was mainly driven by favorable EUR/USD exchange rate movements, resulting in a foreign currency gain of US$2.6 million in 2026, compared to a loss of US$0.4 million in the third quarter of 2025.

The Company had a net profit of US$22.4 million, compared to a net profit of US$7.5 million in the third quarter of 2025. This increase was primarily driven by higher revenues and a favorable change in the net finance result.

Cash generated from operations amounted to US$32.4 million, broadly in line with US$32.0 million in the third quarter of 2025. Cash and cash equivalents, restricted cash and marketable securities increased by US$31.4 million from US$159.5 million at the end of the second quarter of 2026 to US$190.9 million at the end of the third quarter of 2026. This increase was primarily driven by net profit, partially offset by unfavorable working capital movements, including an increase in trade and other receivables.

1 Adjusted Operating Profit is a non-IFRS measure used by management to assess underlying operating performance and provides additional insight into the Company’s core operating profitability. It excludes certain non-core items.

Nine months
2026

Total revenues increased 4% during the first nine months of 2026 to US$280.2 million, compared to US$269.6 million during the first nine months of 2025. Total RUCONEST revenues were 3% lower at US$224.5 million, compared to revenues of US$231.2 million for the first nine months of 2025. The decrease in RUCONEST revenues was primarily driven by a decrease in volume. Joenja revenues amounted to US$55.7 million in the first nine months of 2026, a 45% increase compared to the first nine months of 2025. This increase in Joenja revenues was primarily driven by an increase in volume.

Gross profit decreased by US$1.5 million, or 1%, to US$243.7 million, compared to US$245.2 million in the first nine months of 2025, mainly due to manufacturing-related impairments of inventory (US$10.0 million) partially offset by the increase in revenues.

The operating profit amounted to US$26.3 million compared to an operating profit of US$19.6 million in the first nine months of 2025. Excluding US$10.0 million in one-time manufacturing-related impairments of inventory and US$1.7 million in expenses associated with the closure of the production-support site in Évry, France, adjusted operating profit in the first nine months of 2026 amounted to US$38.0 million. Excluding US$10.1 million of non-recurring Abliva acquisition-related expenses, adjusted operating profit in the first nine months of 2025 amounted to US$29.7 million. The improved operating result was primarily driven by an increase in revenues and lower operating expenses, partially offset by manufacturing-related impairments of inventories in 2026.

The finance result (net) and share of result in associates amounted to a gain of US$3.2 million compared to a loss of US$11.6 million in the first nine months of 2025. This improvement was mainly driven by favorable EUR/USD exchange rate movements, resulting in a foreign currency gain of US$7.9 million in the first nine months of 2026, compared to a loss of US$5.0 million in the first nine months of 2025.

The Company had a net profit of US$18.9 million, compared to a net loss of US$2.8 million in the first nine months of 2025. This increase was primarily driven by higher revenues, lower operating expenses and a favorable change in the net finance result.

Cash generated from operations amounted to US$24.7 million, compared to US$44.0 million in the first nine months of 2025. Cash and cash equivalents, restricted cash and marketable securities increased by US$9.8 million from US$181.1 million at the end of 2025 to US$190.9 million at the end of the third quarter of 2026. This increase was primarily driven by net profit, partially offset by US$12.3 million settlement of the lease liability following the early termination of the DSP facility lease at Pivot Park in Oss, the Netherlands, in the first quarter of 2026.

Outlook/Summary

For 2026, the Company anticipates:

  • Total revenues between US$380.0 million and US$390.0 million (1% to 4% growth).
  • Total operating expenses between US$310.0 million and US$315.0 million (0% to 1% growth), including approximately US$35 million incremental R&D investment to advance the pipeline and US$9 million structural G&A cost reductions based on the plan announced in October 2025.
  • RUCONEST revenue stabilization and return to growth during second half of 2026, and significant and accelerating annual Joenja U.S. and ex-U.S. growth.
  • Commercial launches for leniolisib for APDS patients 12 years of age or older and for pediatrics in key global markets.
  • Top-line data readouts for the two ongoing leniolisib Phase II clinical trials in PIDs with immune dysregulation, including CVID, to expand the asset’s addressable patient population.
  • Continued progress in enrollment of the pivotal FALCON clinical study for napazimone (KL1333) in mitochondrial DNA-driven primary mitochondrial diseases, with completion of enrollment by the first half of 2027.
  • Enhancing capital efficiency to drive growth and build a leading global rare disease company.
  • Continued focus on potential acquisitions and in-licensing of clinical stage opportunities in rare diseases. Financing, if required, would come via a combination of our strong balance sheet and access to capital markets.

No further specific financial guidance for 2026 is provided.

Trademarks

Joenja® and RUCONEST® are registered trademarks owned by or licensed to Pharming Group N.V. or its affiliates.

Additional information

Presentation

The conference call presentation is available on the Pharming.com website from 07:30 CET today.

Conference Call

The conference call will begin at 13:30 CET/08:30 EDT on Tuesday, October 27. A transcript will be made available on the Pharming.com website in the days following the call.

Please note, the Company will only take questions from dial-in attendees.

Webcast Link:


https://edge.media-server.com/mmc/p/nnjperkk

Conference call dial-in details:


https://register-conf.media-server.com/register/BI6feabfc862ab4ba1bc7e6386d00414a3

Additional information on how to register for the conference call/webcast can be found on the Pharming.com website.

For further public information, contact:

Pharming

Michael Levitan, VP Investor Relations & Capital Markets
T: +1 (908) 705 1696
E: [email protected]

Saskia Mehring, Head of Corporate Communications
T: +31 6 28 32 60 41
E: [email protected]

Media Relations

Julia Deutsch (Lyra Strategic Advisory on behalf of Pharming)
E: [email protected]

Netherlands: Leon Melens (LifeSpring Life Sciences Communication on behalf of Pharming)
T: +31 6 53 81 64 27

About Pharming Group N.V.

Pharming Group N.V. (Euronext Amsterdam: PHARM/Nasdaq: PHAR) is a global biotechnology company that develops and commercializes innovative medicines for people living with rare immune and genetic diseases.

We combine specialized scientific, medical, regulatory and commercial expertise to advance a focused portfolio of approved medicines and development programs that address significant unmet medical needs. Guided by insights from patients and the wider rare disease community, we are dedicated to delivering innovative therapies for some of the most challenging rare diseases.

Pharming is headquartered in Leiden, the Netherlands, with operations in the United States and Europe.

For more information, visit www.pharming.com and find us on LinkedIn.

Auditor’s involvement

The Condensed Consolidated Interim Financial Statements have not been audited by the Company’s statutory auditor.

Forward-looking Statements

This press release may contain forward-looking statements. Forward-looking statements are statements of future expectations that are based on management’s current expectations and assumptions and involve known and unknown risks and uncertainties that could cause actual results, performance, or events to differ materially from those expressed or implied in these statements. These forward-looking statements are identified by their use of terms and phrases such as “aim”, “ambition”, “anticipate”, “believe”, “could”, “estimate”, “expect”, “goals”, “intend”, “may”, “milestones”, “objectives”, “outlook”, “plan”, “probably”, “project”, “risks”, “schedule”, “see”, “should”, “target”, “will” and similar terms and phrases. Examples of forward-looking statements may include statements with respect to timing and progress of Pharming’s preclinical studies and clinical trials of its product candidates, Pharming’s clinical and commercial prospects, and Pharming’s expectations regarding its projected working capital requirements and cash resources, which statements are subject to a number of risks, uncertainties and assumptions, including, but not limited to the scope, progress and expansion of Pharming’s clinical trials and ramifications for the cost thereof; and clinical, scientific, regulatory, commercial, competitive and technical developments. In light of these risks and uncertainties, and other risks and uncertainties that are described in Pharming’s 2025 Annual Report and the Annual Report on Form 20-F for the year ended December 31, 2025, filed with the U.S. Securities and Exchange Commission, the events and circumstances discussed in such forward-looking statements may not occur, and Pharming’s actual results could differ materially and adversely from those anticipated or implied thereby. All forward-looking statements contained in this press release are expressly qualified in their entirety by the cautionary statements contained or referred to in this section. Readers should not place undue reliance on forward-looking statements. Any forward-looking statements speak only as of the date of this press release and are based on information available to Pharming as of the date of this release. Pharming does not undertake any obligation to publicly update or revise any forward-looking statement as a result of new information, future events or other information.

Inside Information

This press release relates to the disclosure of information that qualifies, or may have qualified, as inside information within the meaning of Article 7(1) of the EU Market Abuse Regulation.

Pharming Group N.V.

Condensed Consolidated Interim Financial Statements in US Dollars (unaudited)

For the period ended September 30, 2026

  • Condensed consolidated interim statement of income
  • Condensed consolidated interim statement of comprehensive income
  • Condensed consolidated interim balance sheet
  • Condensed consolidated interim statement of changes in equity
  • Condensed consolidated interim statement of cash flows
CONDENSED CONSOLIDATED INTERIM STATEMENT OF INCOME
For the period ended September 30
 
Amounts in US$ ‘000 9M 2026 9M 2025
Revenues 280,217 269,602
Costs of sales (36,553) (24,366)
Gross profit 243,664 245,236
Other income 4,097 2,303
Research and development (87,389) (68,221)
General and administrative (45,738) (59,945)
Marketing and sales (88,345) (99,746)
Other Operating Costs (221,472) (227,911)
Operating profit (loss) 26,289 19,628
Fair value gain (loss) on revaluation — —
Other finance income 11,152 1,748
Other finance expenses (8,144) (13,048)
Finance result, net 3,008 (11,300)
Share of net profits (loss) in associates using the equity method 233 (279)
Profit (loss) before tax 29,530 8,049
Income tax credit (expense) (10,677) (10,838)
Profit (loss) for the period 18,853 (2,790)
Attributable to:    
Equity holders of the parent 18,853 (2,477)
Non-controlling interests — (313)
     
Earnings per share    
Basic, attributable to equity holders of the parent (US$) 0.027 (0.004)
Diluted, attributable to equity holders of the parent (US$) 0.025 (0.004)

CONDENSED CONSOLIDATED INTERIM STATEMENT OF COMPREHENSIVE INCOME
For the period ended September 30
 
Amounts in US$ ‘000 9M 2026 9M 2025
Profit (loss) for the period 18,853 (2,790)
Currency translation differences (11,258) 26,092
Items that may be subsequently reclassified to profit or loss (11,258) 26,092
Fair value remeasurement investments — —
Items that shall not be subsequently reclassified to profit or loss — —
Other comprehensive income (loss), net of tax (11,258) 26,092
Total comprehensive income (loss) for the period 7,595 23,303
Attributable to:    
Equity holders of the parent 7,595 23,616
Non-controlling interests — (313)

CONDENSED CONSOLIDATED INTERIM BALANCE SHEET    
     
Amounts in US$ ‘000 September 30, 2026 December 31, 2025
Non-current assets    
Intangible assets 125,667 135,538
Property, plant and equipment 6,165 7,233
Right-of-use assets 13,335 16,738
Long-term prepayments 91 94
Deferred tax assets 19,051 31,017
Investment accounted for using the equity method 2,109 1,944
Investment in debt instruments designated as at FVTPL 6,485 6,703
Restricted cash 1,355 1,227
Total non-current assets 174,258 200,495
Current assets    
Inventories 57,988 64,902
Trade and other receivables 74,831 54,704
Restricted cash — 761
Marketable securities — 33,796
Cash and cash equivalents 189,560 145,305
Total current assets 322,379 299,469
Total assets 496,637 499,963
Equity    
Share capital 8,086 8,009
Share premium 520,912 513,257
Other reserves 17,518 28,819
Accumulated deficit (255,277) (272,983)
Shareholders’ equity 291,239 277,102
Non-current liabilities    
Convertible bonds 94,344 92,719
Lease liabilities 11,102 14,351
Total non-current liabilities 105,446 107,070
Current liabilities    
Convertible bonds 5,584 5,336
Provisions 816 1,187
Trade and other payables 90,069 105,899
Lease liabilities 3,483 3,369
Total current liabilities 99,952 115,791
Total equity and liabilities 496,637 499,963

CONDENSED CONSOLIDATED INTERIM STATEMENT OF CHANGES IN EQUITY    
For the period ended September 30    
Attributable to owners of the parent    
               
Amounts in US$ ‘000 Share capital Share premium Other reserves Accumulated deficit Total Non-controlling interests Total equity
Balance at January 1, 2025 7,769 488,990 (209) (275,489) 221,061 — 221,061
Profit (loss) for the period — — — (2,477) (2,477) (313) (2,790)
Reserves — — — — — — —
Other comprehensive income (loss) for the period — — 26,092 — 26,092 — 26,092
Total comprehensive income (loss) for the period — — 26,092 (2,477) 23,616 (313) 23,303
Other reserves — — (32) 32 — — —
Income tax benefit from excess tax deductions related to share-based payments — — — 807 807 — 807
Share-based compensation — — — 9,256 9,256 — 9,256
Options exercised / LTIP shares issued 184 18,727 — (8,320) 10,592 — 10,592
Acquisition of a subsidiary — — — — — 7,741 7,741
Acquisition of non-controlling interests — — — (687) (687) (7,428) (8,115)
Total transactions with owners, recognized directly in equity 184 18,727 (32) 1,087 19,967 313 20,280
Balance at September 30, 2025 7,953 507,717 25,852 (276,878) 264,644 — 264,644
               
Balance at January 1, 2026 8,009 513,257 28,819 (272,983) 277,102 — 277,102
Profit (loss) for the period — — — 18,853 18,853 — 18,853
Reserves — — — — — — —
Other comprehensive income (loss) for the period — — (11,258) — (11,258) — (11,258)
Total comprehensive income (loss) for the period — — (11,258) 18,853 7,595 — 7,595
Other reserves — — (43) 34 (9) — (9)
Income tax benefit from excess tax deductions related to share-based payments — — — (629) (629) — (629)
Share-based compensation — — — 8,353 8,353 — 8,353
Options exercised / LTIP shares issued 77 7,655 — (8,905) (1,173) — (1,173)
Total transactions with owners, recognized directly in equity 77 7,655 (43) (1,147) 6,542 — 6,542
Balance at September 30, 2026 8,086 520,912 17,518 (255,277) 291,239 — 291,239

CONDENSED CONSOLIDATED INTERIM STATEMENT OF CASH FLOWS
For the period ended September 30
 
Amounts in $’000 9M 2026 9M 2025
Profit (loss) before tax 29,530 8,049

Adjustments to reconcile net profit (loss) to net cash used in operating activities:
   
Depreciation, amortization, impairment of non-current assets 8,745 8,010
Equity settled share based payments 8,353 9,256
Loss (gain) on disposal of leases (2) (9)
Impairments of inventories¹ 11,777 2,183
Other finance income (11,152) (1,748)
Other finance expenses 8,088 12,837
Share of net result in associates using the equity method (233) 279
Operating cash flows before changes in working capital 55,106 38,857

Changes in working capital:
   
Inventories¹ (5,372) (5,686)
Provisions (371) —
Trade and other receivables (14,801) 11,453
Payables and other current liabilities (4,797) 4,138
Restricted cash 569 (1,018)
Total changes in working capital (24,772) 8,887
     
Interest received 2,991 1,723
Income taxes received (paid) (8,660) (5,466)
Net cash flows generated from (used in) operating activities 24,665 44,001
     
Capital expenditure for property, plant and equipment (601) (480)
Investment intangible assets — (6)
Investment in associates using the equity method — (731)
Purchases of marketable securities (102,646) —
Proceeds from sale of marketable securities 18,124 84,990
Acquisition of a subsidiary, net of cash acquired — (57,476)
Net cash flows generated from (used in) investing activities (85,123) 26,297
     
Payment of lease liabilities (14,803) (2,877)
Interests on lease liabilities (349) (848)
Interests on convertible bonds (2,614) (2,506)
Settlement of share based compensation awards 5,703 14,564
Acquisition of non-controlling interests — (7,876)
Net cash flows generated from (used in) financing activities (12,063) 457
     
Increase (decrease) of cash (72,521) 70,755
Exchange rate effects (1,020) 6,672
Effect of reclassification of money market funds to cash and cash equivalents2 117,796 —
Cash and cash equivalents at the beginning of the period 145,305 54,944
     
Total cash and cash equivalents at September 30 189,560 132,370


1 Comparative presentation updated for consistency.
2 Money market funds are classified as cash equivalents from April 1, 2026

Attachment



Innate Pharma: PACIFIC-9 Phase 3 Trial Readout Timing Updated to H1 2027

Innate Pharma: PACIFIC-9 Phase 3 Trial Readout Timing Updated to H1 2027

  • PACIFIC-9 Phase 3 trial led by AstraZeneca evaluates durvalumab in combination with monalizumab or oleclumab in unresectable Stage III NSCLC

MARSEILLE, France–(BUSINESS WIRE)–
Regulatory News:

Innate Pharma SA (Euronext Paris: IPH; Nasdaq: IPHA) (“Innate” or the “Company”) today announced that AstraZeneca has updated the expected timing for the PACIFIC-9 Phase 3 trial high-level data readout to the first half of 2027, from the second half of 2026 previously. The revised timing reflects the event-driven nature of the study.

PACIFIC-9 is an AstraZeneca-led Phase 3 trial evaluating durvalumab in combination with monalizumab or oleclumab in patients with unresectable Stage III non-small cell lung cancer (NSCLC) who have not progressed following platinum-based chemoradiation therapy. Enrollment in the trial is complete.

Monalizumab is an anti-NKG2A antibody developed by Innate Pharma in collaboration with AstraZeneca. AstraZeneca obtained full oncology rights to monalizumab in October 2018 through a co-development and commercialisation agreement initiated in 2015.

About Innate Pharma

Innate Pharma S.A. is a global, clinical-stage biotechnology company developing immunotherapies for cancer patients. Leveraging its expertise in antibody engineering and innovative target identification, Innate Pharma is developing innovative and differentiated next-generation antibody therapeutics.

Innate Pharma is advancing a portfolio of differentiated potential first- and/or best-in-class assets, focused on areas of high unmet medical need. Its proprietary pipeline is centered on antibody-drug conjugates (ADCs), led by IPH4502, a differentiated Nectin-4 ADC in clinical development for solid tumors, and supported by a preclinical portfolio of next-generation ADC candidates. In parallel, Innate is advancing two partnered late-stage assets: lacutamab, developed with Sobi for T-cell lymphomas, and monalizumab, developed with AstraZeneca for non-small cell lung cancer (NSCLC).

Innate Pharma has established collaborations with leading biopharmaceutical companies, including Sobi, Sanofi and AstraZeneca, as well as renowned academic and research institutions, to advance innovation in immuno-oncology.

Headquartered in Marseille, France, Innate Pharma is listed on Euronext Paris and Nasdaq in the US.

Learn more about Innate Pharma at www.innate-pharma.com and follow us on LinkedIn and X.

Information about Innate Pharma shares

ISIN code: FR0010331421

Ticker code: Euronext Paris: IPH | Nasdaq: IPHA

LEI: 9695002Y8420ZB8HJE29

Disclaimer on forward-looking information and risk factors

For a discussion of risks and uncertainties, please refer to the Risk Factors (“Facteurs de Risque”) section of the Universal Registration Document filed with the French Financial Markets Authority (“AMF”), which is available on the AMF website http://www.amf-france.org or on Innate Pharma’s website, and public filings and reports filed with the U.S. Securities and Exchange Commission (“SEC”), including the Company’s Annual Report on Form 20-F for the year ended December 31, 2025, and subsequent filings and reports filed with the AMF or SEC, or otherwise made public by the Company. References to the Company’s website and the AMF website are included for information only and the content contained therein, or that can be accessed through them, are not incorporated by reference into, and do not constitute a part of, this press release.

This press release and the information contained herein do not constitute an offer to sell or a solicitation of an offer to buy or subscribe to shares in Innate Pharma in any country.

Stéphanie Cornen

VP, Investor Relations & Corporate Communications

[email protected]

Investor Relations

[email protected]

Media

[email protected]

KEYWORDS: Maryland Europe United States North America France

INDUSTRY KEYWORDS: Oncology Health Other Health Clinical Trials Pharmaceutical Biotechnology

MEDIA:

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NVIDIA and Meta to Expand Collaboration on Muse and Muse Family of Models Amid Robust Growth

News Summary:

  • NVIDIA and Meta will expand their partnership on Muse and the Muse family of models, reflecting popular demand for AI agents.
  • The companies are also considering other technological collaborations, including NVIDIA OpenShell Reference Architecture to strengthen agency security and NVIDIA Sentry for monitoring, structured, unstructured and graph data processing.
  • Meta to expand NVIDIA Vera Rubin and Vera CPU deployment to boost performance and scale workloads with NVIDIA Spectrum-X Ethernet networking and BlueField-4.

SANTA CLARA, Calif., Oct. 27, 2026 (GLOBE NEWSWIRE) — NVIDIA and Meta today announced they will partner to expand their work on Muse and the Muse family of models to improve inference and training performance, reflecting popular demand for useful AI agents.

Meta’s Muse models and agents, which leverage NVIDIA’s infrastructure, have delivered frontier-level benchmark performance and surging consumer downloads since launch. Meta and NVIDIA intend to further deepen their collaboration by partnering on optimizations across workflows to maximize performance and improve total cost of ownership. Meta and NVIDIA will also consider additional collaboration opportunities with NVIDIA on its NVIDIA OpenShell Reference Architecture, including NVIDIA OpenShell™ for safe deployment and NVIDIA Sentry for monitoring agent behavior.

This announcement reinforces Meta and NVIDIA’s strong long-term partnership to support Meta’s AI infrastructure ambitions. Meta intends to expand the deployment of NVIDIA infrastructure, including Vera Rubin and Vera CPUs for next-generation AI agents to deliver maximum performance per watt. Meta will also deploy NVIDIA Spectrum-X™ Ethernet networking and BlueField-4® to support network efficiency and throughput.

In addition, NVIDIA will invest $3 billion in Meta’s equity offering.

“AI agents represent a new computing paradigm — software that understands our goals, reasons, uses tools and gets work done on our behalf,” said Jensen Huang, founder and CEO of NVIDIA. “This changes how we use computers, from operating applications to working with intelligent agents. NVIDIA and Meta are expanding our partnership to optimize the computing infrastructure end to end for capable, efficient and secure AI agents, so Muse can empower billions of people to achieve more and pursue greater ambitions.”

“Muse is how we bring personal superintelligence to everyone. We’re excited to keep working with NVIDIA to deliver the best personal agents and frontier models for billions of people,” said Mark Zuckerberg, founder and CEO of Meta.

About NVIDIA

NVIDIA (NASDAQ: NVDA) is the world leader in AI and accelerated computing.

For further information, contact:

Mylene Mangalindan
Corporate Communications
NVIDIA Corporation
[email protected] 

Toshiya Hari
Investor Relations
NVIDIA Corporation
[email protected]

NVIDIA Forward-Looking Statements

Certain statements in this press release including, but not limited to, statements as to: expectations with respect to NVIDIA’s proposed investment in Meta, including its anticipated completion and any applicable closing conditions; expectations with respect to growth, performance, availability, and benefits of NVIDIA’s products, services and technologies, and related trends and drivers; expectations with respect to NVIDIA’s third party arrangements, including with its collaborators and partners; expectations with respect to technology developments, and related trends and drivers; projected market growth and trends; expectations with respect to AI and related industries; and other statements that are not historical facts are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to the “safe harbor” created by those sections based on management’s beliefs and assumptions and on information currently available to management and are subject to risks and uncertainties that could cause results to be materially different than expectations. Important factors that could cause actual results to differ materially include: global economic and political conditions; NVIDIA’s reliance on third parties to manufacture, assemble, package and test NVIDIA’s products; the impact of technological development and competition; development of new products and technologies or enhancements to NVIDIA’s existing products and technologies; market acceptance of NVIDIA’s products or NVIDIA’s partners’ products; design, manufacturing or software defects; changes in consumer preferences or demands; changes in industry standards and interfaces; unexpected loss of performance of NVIDIA’s products or technologies when integrated into systems; NVIDIA’s ability to realize the potential benefits of business investments or acquisitions; and changes in applicable laws and regulations, as well as other factors detailed from time to time in the most recent reports NVIDIA files with the Securities and Exchange Commission, or SEC, including, but not limited to, its Annual Report on Form 10-K and Quarterly Reports on Form 10-Q. Copies of reports filed with the SEC are posted on NVIDIA’s website and are available from NVIDIA without charge. These forward-looking statements are not guarantees of future performance and speak only as of the date hereof, and, except as required by law, NVIDIA disclaims any obligation to update these forward-looking statements to reflect future events or circumstances.

© 2026 NVIDIA Corporation. All rights reserved. NVIDIA, the NVIDIA logo, and other NVIDIA product and service names are trademarks and/or registered trademarks of NVIDIA Corporation in the U.S. and other countries and regions. Other company, product, and service names may be trademarks of the respective companies with which they are associated.

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FTI Consulting Continues Growth of Middle East Tax Practice With Appointment of Sandeep Kumar as Senior Managing Director

 Senior appointment strengthens UAE corporate and international tax leadership to help clients navigate complex corporate and international tax requirements

DUBAI, United Arab Emirates, Oct. 27, 2026 (GLOBE NEWSWIRE) — FTI Consulting, Inc. (NYSE: FCN) today announced the appointment of Sandeep Kumar as a Senior Managing Director in the Tax practice within the firm’s Corporate Finance segment, reflecting increasing client demand for practical UAE corporate tax, international tax and technology-enabled compliance support.

Mr. Kumar, who is based in Dubai, will help listed companies, multinationals and family-owned groups navigate UAE corporate tax and international tax matters by providing practical advice across structuring, cross-border transactions, compliance, engagement with the tax authority and technology-enabled transformation of the tax function.

“Sandeep’s appointment marks an important next step in the growth of our Tax practice in the Middle East,” said Nilesh Ashar, a Senior Managing Director and Head of Middle East Tax at FTI Consulting. “Since the introduction of UAE corporate tax, Sandeep has worked with businesses across the full lifecycle, from initial impact assessment and implementation through compliance, clarifications and tax return filings. His combination of technical expertise, sector knowledge and experience developing technology-enabled solutions will add meaningful value for clients as they respond to a rapidly evolving regional tax environment.”

Mr. Kumar brings 17 years of corporate and international tax experience, with approximately a decade of it in the GCC. He has advised clients across the oil and gas, utilities, real estate, education, retail and consumer sectors, and has represented clients before the tax authority, supported complex private clarification requests and assisted in developing tax technology solutions to improve corporate tax compliance.

“Sandeep’s experience will strengthen the connectivity between our regional Tax team and our wider EMEA capabilities,” said Euan Sutherland, Head of EMEA Tax at FTI Consulting. “His understanding of UAE corporate tax, international tax and technology-enabled compliance will be valuable to organisations managing increasingly complex obligations across jurisdictions in the region. He also brings a strong commitment to developing people and sharing technical knowledge, which will support the continued growth of our team.”

Prior to joining FTI Consulting, Mr. Kumar was a partner at a leading tax advisory firm in the UAE, where he built and led the corporate tax team and headed its learning and development and thought leadership programme. He previously held senior tax roles in the Big Four accounting firms in the UAE, India and Oman. Mr. Kumar is a Chartered Accountant (ICAI) and holds the IBFD Advanced Professional Certificate in International Taxation (APCIT).

Commenting on his appointment, Mr. Kumar said, “UAE corporate tax has moved quickly from implementation to a phase of closer scrutiny, and businesses now need advice that combines technical depth with practical, commercially grounded solutions. I look forward to working with Nilesh and expert colleagues across the region, Corporate Finance and EMEA to build a UAE corporate tax practice that clients rely on for exactly that, and to develop the next generation of tax talent along the way.”

About FTI Consulting

FTI Consulting, Inc. is a leading global expert firm for organisations facing crisis and transformation, with more than 8,100 employees located in 32 countries and territories as of June 30, 2026. In certain jurisdictions, FTI Consulting’s services are provided through distinct legal entities that are separately capitalised and independently managed. The Company generated $3.8 billion in revenues during fiscal year 2025. More information can be found at www.fticonsulting.com.

FTI Consulting, Inc.  
200 Aldersgate
Aldersgate Street
London, EC1A 4HD

Investor Contact:  
Mollie Hawkes 
+1.617.747.1791 
[email protected] 

Media Contact:  
[email protected]



SPACCircle Acquisition Corp. Announces the Pricing of $100 Million Initial Public Offering

SACRAMENTO, Oct. 26, 2026 (GLOBE NEWSWIRE) — SPACCircle Acquisition Corp. (the “Company”) announced the pricing of its initial public offering of 10,000,000 units at $10.00 per unit. The units will be listed on the Nasdaq Global Market (“Nasdaq”) under the symbol “SCQCU” commencing today. Each unit consists of one Class A ordinary share of the Company, one redeemable warrant, entitling the holder thereof to purchase one Class A ordinary share of the Company at an exercise price of $11.50 per share and one right to receive one half (1/2) of one Class A ordinary share upon the consummation of an initial business combination. Once the securities comprising the units begin separate trading, the Company expects that the Class A ordinary shares, warrants and rights will be listed on Nasdaq under the symbols “SCQC,” “SCQCW” and “SCQCR” respectively. The offering is expected to close on October 28, 2026, subject to customary closing conditions. 

The Company was formed for the purpose of effecting a merger, amalgamation, share exchange, asset acquisition, share purchase, reorganization or similar business combination with one or more businesses. It may pursue an initial business combination target in any business or industry.

D. Boral is acting as sole book-running manager for the offering. The Company has granted the underwriters a 45-day option to purchase up to an additional 1,500,000 units at the initial public offering price to cover over-allotments, if any.

The offering is being made only by means of a prospectus, copies of which may be obtained from D. Boral Capital LLC, 590 Madison Avenue, 39th Floor, New York, NY 10022, or via email at [email protected], or by accessing the U.S. Securities and Exchange Commission’s (the “SEC”) website at www.sec.gov.

A registration statement relating to these securities has been declared effective by the SEC. This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.


FORWARD-LOOKING STATEMENTS

This press release contains statements that constitute “forward-looking statements,” including with respect to the proposed initial public offering and the anticipated use of the net proceeds. No assurance can be given that the offering discussed above will be completed on the terms described, or at all, or that the net proceeds of the offering will be used as indicated. Forward-looking statements are subject to numerous conditions, many of which are beyond the control of the Company, including those set forth in the Risk Factors section of the Company’s registration statement and preliminary prospectus for the Company’s offering filed with the SEC. Copies are available on the SEC’s website,

www.sec.gov

. The Company undertakes no obligation to update these statements for revisions or changes after the date of this release, except as required by law.

Company Contact:  
SPACCircle Acquisition Corp.
John Dicconson
Chief Executive Officer and Chairman
831-236-7207