Bristol Myers Squibb Reports Fourth Quarter and Full-Year Financial Results for 2024

Bristol Myers Squibb Reports Fourth Quarter and Full-Year Financial Results for 2024

Performance Reflects Progress Toward Delivering Sustained, Top-Tier Growth

  • Fourth Quarter Revenues were $12.3 Billion, Increasing 8% (+9% Adjusting for Foreign Exchange); GAAP Earnings Per Share (EPS) was $0.04 and Non-GAAP EPS was $1.67
    • Growth Portfolio Revenues were $6.4 Billion, Increasing 21% (+23% Adjusting for Foreign Exchange)
  • Full-Year Revenues were $48.3 Billion, Increasing 7% (+9% Adjusting for Foreign Exchange); GAAP Loss Per Share was $(4.41) and Non-GAAP EPS was $1.15; Includes Net Impact of $(6.39) Per Share for GAAP and Non-GAAP EPS Due to Acquired IPRD Charges and Licensing Income
    • Growth Portfolio Revenues were $22.6 Billion, Increasing 17% (+19% Adjusting for Foreign Exchange)
  • Achieved Multiple Clinical and Regulatory Milestones in the Fourth Quarter, Including U.S. Approval of Opdivo Qvantig and theU.S. Launch of Cobenfy
  • Expands Strategic Productivity Initiative to Deliver ~$2 Billion in Additional Cost Savings by the End of 2027
  • Provides 2025 Guidance with Revenues of ~$45.5 Billion; Non-GAAP EPS Range of $6.55 to $6.85

PRINCETON, N.J.–(BUSINESS WIRE)–Bristol Myers Squibb (NYSE: BMY) today reports results for the fourth quarter and full year of 2024.

“We made good progress in 2024, which was capped by a fourth quarter of strong topline growth driven by key products and important pipeline advancements. We also achieved the landmark U.S. approval of Cobenfy last year for the treatment of schizophrenia in adults, and we expect this medicine to have a meaningful impact on patients and the company as a new growth driver,” said Christopher Boerner, Ph.D., board chair and chief executive officer, Bristol Myers Squibb. “Our collective focus on execution has established a solid foundation to navigate the multi-year journey toward achieving top-tier sustainable growth and long-term shareholder returns.”

 

Fourth Quarter

$ in millions, except per share amounts

2024

 

2023

 

Change

 

Change

Excl. F/X**

Total Revenues

$12,342

 

$11,477

 

 

8%

 

9%

Earnings Per Share – GAAP*

0.04

 

0.87

 

 

(95)%

 

N/A

Earnings Per Share – Non-GAAP*

1.67

 

1.70

 

 

(2)%

 

N/A

Acquired IPRD Charge and Licensing Income Net Impact on Earnings Per Share

0.01

 

(0.20

)

 

N/A

 

N/A

*GAAP and Non-GAAP earnings per share include the net impact of Acquired IPRD charges and licensing income.

**See “Use of Non-GAAP Financial Information”.

 

Full Year

$ in millions, except per share amounts

2024

 

2023

 

Change

 

Change

Excl. F/X**

Total Revenues

$48,300

 

 

$45,006

 

 

7%

 

9%

(Loss)/Earnings Per Share – GAAP*

(4.41

)

 

3.86

 

 

N/A

 

N/A

Earnings Per Share – Non-GAAP*

1.15

 

 

7.51

 

 

(85)%

 

N/A

Acquired IPRD Charge and Licensing Income Net Impact on Earnings Per Share

(6.39

)

 

(0.28

)

 

N/A

 

N/A

*GAAP and Non-GAAP earnings per share include the net impact of Acquired IPRD charges and licensing income.

**See “Use of Non-GAAP Financial Information”.

FOURTH QUARTER RESULTS

All comparisons are made versus the same period in 2023 unless otherwise stated.

  • Bristol Myers Squibb posted fourth quarter revenues of $12.3 billion, an increase of 8%, or 9% when adjusted for foreign exchange impacts, primarily driven by the Growth Portfolio and higher demand for Eliquis, partially offset by the impact of generics on Sprycel, Revlimid, Abraxane and Pomalyst.

    • U.S. revenues increased 9% to $8.6 billion, primarily driven by higher demand for the Growth Portfolio and Eliquis, partially offset by the impact of generics within the Legacy Portfolio.

    • International revenues increased 5% to $3.7 billion, or 9% when adjusted for foreign exchange impacts, primarily driven by higher demand for the Growth Portfolio, partially offset by the impact of generics within the Legacy Portfolio.

  • On a GAAP basis, gross margin decreased from 76.1% to 61.0%, primarily driven by intangible asset impairment charges and product mix. On a non-GAAP basis, gross margin decreased from 76.4% to 74.0%, primarily due to product mix.

  • On a GAAP and non-GAAP basis, marketing, selling and administrative expenses remained relatively flat at $2.1 billion.

  • On a GAAP basis, research and development expenses increased 29% to $3.2 billion, primarily due to the impact of recent acquisitions and IPRD impairment charges. On a non-GAAP basis, research and development expenses increased 13% to $2.8 billion, primarily due to the impact of recent acquisitions.

  • On a GAAP and non-GAAP basis, Acquired IPRD decreased to $30 million from $600 million. On a GAAP and non-GAAP basis, licensing income was $48 million compared to $67 million.

  • On a GAAP basis, amortization of acquired intangible assets decreased 26% to $1.7 billion, primarily due to lower amortization expense related to Revlimid, partially offset by the RayzeBio acquisition in 2024.

  • On a GAAP basis, the effective tax rate was 56.6%, primarily due to the impact of intangible asset impairments and amortization of acquired intangible assets. In 2023, the income tax benefit was $88 million despite pre-tax earnings of $1.7 billion, primarily due to a valuation allowance reversal and foreign currency. On a non-GAAP basis, the effective tax rate changed from 14.9% to 19.9%, primarily due to jurisdictional earnings mix.

  • On a GAAP basis, the company reported net income attributable to Bristol Myers Squibb of $72 million, or $0.04 per share, during the fourth quarter of 2024 compared to net earnings of $1.8 billion, or $0.87 per share, for the same period a year ago. The company reported non-GAAP net earnings attributable to Bristol Myers Squibb of $3.4 billion, or $1.67 per share, during the fourth quarter of 2024 compared to $3.5 billion, or $1.70 per share, for the same period a year ago.

FOURTH QUARTER PRODUCT REVENUE HIGHLIGHTS

 

($ amounts in millions)

 

Quarter Ended December

31, 2024

 

% Change from Quarter

Ended December 31,

2023

 

% Change from

Quarter Ended

December 31,

2023 Ex-F/X**

 

 

U.S.

 

Int’l(c)

 

WW(d)

 

U.S.

 

Int’l(c)

 

WW(d)

 

Int’l(c)

 

WW(d)

Growth Portfolio

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Opdivo

 

$

1,423

 

$

1,056

 

$

2,479

 

2%

 

7%

 

4%

 

15%

 

7%

Orencia

 

 

750

 

 

250

 

 

1,000

 

(1)%

 

9%

 

2%

 

15%

 

3%

Yervoy

 

 

428

 

 

247

 

 

675

 

26%

 

9%

 

19%

 

15%

 

22%

Reblozyl

 

 

445

 

 

102

 

 

547

 

65%

 

104%

 

71%

 

110%

 

72%

Opdualag

 

 

233

 

 

21

 

 

254

 

25%

 

>200%

 

34%

 

>200%

 

34%

Breyanzi

 

 

209

 

 

54

 

 

263

 

146%

 

>200%

 

160%

 

>200%

 

162%

Camzyos

 

 

201

 

 

22

 

 

223

 

142%

 

>200%

 

153%

 

>200%

 

153%

Zeposia

 

 

115

 

 

43

 

 

158

 

15%

 

30%

 

19%

 

33%

 

20%

Abecma

 

 

59

 

 

46

 

 

105

 

5%

 

5%

 

5%

 

5%

 

5%

Sotyktu

 

 

64

 

 

19

 

 

83

 

14%

 

171%

 

32%

 

171%

 

32%

Krazati

 

 

36

 

 

3

 

 

39

 

N/A

 

N/A

 

N/A

 

N/A

 

N/A

Augtyro

 

 

13

 

 

2

 

 

15

 

>200%

 

N/A

 

>200%

 

N/A

 

>200%

Cobenfy

 

 

10

 

 

 

 

10

 

N/A

 

N/A

 

N/A

 

N/A

 

N/A

Other Growth Products(a)

 

 

186

 

 

326

 

 

512

 

13%

 

104%

 

58%

 

106%

 

59%

Total Growth Portfolio

 

 

4,172

 

 

2,191

 

 

6,363

 

19%

 

24%

 

21%

 

31%

 

23%

Legacy Portfolio

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Eliquis

 

 

2,221

 

 

974

 

 

3,195

 

19%

 

(3)%

 

11%

 

(2)%

 

11%

Revlimid

 

 

1,169

 

 

170

 

 

1,339

 

(6)%

 

(17)%

 

(8)%

 

(15)%

 

(7)%

Pomalyst/Imnovid

 

 

685

 

 

138

 

 

823

 

9%

 

(48)%

 

(8)%

 

(47)%

 

(7)%

Sprycel

 

 

135

 

 

63

 

 

198

 

(67)%

 

(45)%

 

(62)%

 

(41)%

 

(61)%

Abraxane

 

 

91

 

 

83

 

 

174

 

(48)%

 

17%

 

(30)%

 

28%

 

(26)%

Other Legacy Products(b)

 

 

123

 

 

127

 

 

250

 

46%

 

(14)%

 

8%

 

(15)%

 

7%

Total Legacy Portfolio

 

 

4,424

 

 

1,555

 

 

5,979

 

—%

 

(14)%

 

(4)%

 

(12)%

 

(3)%

Total Revenues

 

$

8,596

 

$

3,746

 

$

12,342

 

9%

 

5%

 

8%

 

9%

 

9%

**

See “Use of Non-GAAP Financial Information”.

(a)

Includes Nulojix, Onureg, Inrebic, Empliciti and royalty revenue.

(b)

Includes other mature brands.

(c)

Beginning in 2024, Puerto Rico revenues are included in International revenues. Prior period amounts have been reclassified to conform to the current presentation.

(d)

Worldwide (WW) includes U.S. and International (Int’l).

FOURTH QUARTER PRODUCT REVENUE HIGHLIGHTS

Growth Portfolio

Growth Portfolio worldwide revenues increased to $6.4 billion compared to $5.3 billion in the prior year period, representing growth of 21% on a reported basis, or 23% when adjusted for foreign exchange impacts. Growth Portfolio revenues were primarily due to higher demand for Reblozyl,Breyanzi, Camzyos, Yervoy and Opdualag.

Legacy Portfolio

Revenues for the Legacy Portfolio in the fourth quarter were $6.0 billion compared to $6.2 billion in the prior year period, representing a decline of 4% on a reported basis and 3% when adjusted for foreign exchange impacts. Legacy Portfolio revenues were lower primarily due to the impact of generics on Sprycel, Revlimid, Abraxane and Pomalyst, partially offset by higher demand for Eliquis.

PRODUCT AND PIPELINE UPDATE

Neuroscience

Category

Asset

Milestone

Clinical &

Research

CobenfyTM(xanomeline and trospium chloride)

Long-term data from the Phase 3 EMERGENT-4 and EMERGENT-5 trials evaluating Cobenfy in adults with schizophrenia showed that Cobenfy was generally well tolerated over 52 weeks, with continued improvements in symptoms and a side effect profile consistent with prior trials of the treatment in this indication.

Oncology

Category

Asset

Milestone

Regulatory

Opdivo®(nivolumab)+ Yervoy® (ipilimumab)

The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) recommended approval of Opdivo + Yervoy for the first-line treatment of adult patients with unresectable or advanced hepatocellular carcinoma. The recommendation is based on results of the Phase 3 CheckMate -9DW trial. The CHMP opinion will now be reviewed by the European Commission (EC), which has the authority to approve medicines for the European Union.

 

AugtyroTM(repotrectinib)*

The EC approved Augtyro, a next-generation tyrosine kinase inhibitor (TKI), as a treatment for adult patients with ROS1-positive advanced non-small cell lung cancer and for the treatment of adult and pediatric patients 12 years of age and older with advanced solid tumors expressing a NTRK gene fusion, and who have received a prior NTRK inhibitor, or have not received a prior NTRK inhibitor and treatment options not targeting NTRK provide limited clinical benefit, or have been exhausted. The approval is based on results from the TRIDENT-1 and CARE trials.

 

*Approval received on January 13, 2025, and announced today by the company.

 

Opdivo QvantigTM(nivolumab and hydaluronidase-nyhy)

The U.S. Food and Drug Administration (FDA) approvedOpdivo Qvantig injection for subcutaneous use in most previously approved adult, solid tumor Opdivo indications as monotherapy, monotherapy maintenance after completion of Opdivo plus Yervoy combination therapy, or in combination with chemotherapy or cabozantinib. The approval is based on results from the Phase 3 randomized, open-label CheckMate -67T trial.

 

Opdivo + Yervoy

The EC approvedOpdivo plus Yervoy for the first-line treatment of adult patients with microsatellite instability-high or mismatch repair deficient unresectable or metastatic colorectal cancer (mCRC). The approval is based on results from the CheckMate -8HW trial.

Clinical &

Research

Opdivo + Yervoy

Results from an analysis of the Phase 3 CheckMate -8HW trial evaluating Opdivo plus Yervoy versus Opdivo monotherapy across all lines of therapy for microsatellite instability-high/mismatch repair-deficient mCRC demonstrated a statistically significant and clinically meaningful improvement at a median follow up of 47 months in the dual primary endpoint of progression-free survival as assessed by Blinded Independent Central Review.

Hematology

Category

Asset

Milestone

Clinical &

Research

Breyanzi® (lisocabtagene maraleucel)

Five-year overall survival data from the Phase 1 TRANSCEND NHL 001 study supported deep and durable responses of Breyanzi in patients with relapsed or refractory large B-cell lymphoma (LBCL) with median overall survival (OS) of 27.5 months and an estimated OS rate at five years of 38 percent. Breyanzi continued to demonstrate an established safety profile with no new safety signals.

 

In addition, new circulating tumor DNA (ctDNA) from the Phase 3 TRANSFORM study supported the superiority of Breyanzi to achieve deeper responses over the former standard of care in second-line LBCL.

Regulatory

Breyanzi

The CHMP of the EMA recommended approval of Breyanzi for the treatment of adult patients with relapsed or refractory follicular lymphoma (FL) who have received two or more prior lines of systemic therapy. The recommendation is based on data from the Phase 2 TRANSCEND FL study. The CHMP opinion will now be reviewed by the EC.

Cardiovascular

Category

Asset

Milestone

Clinical & Research

Camzyos® (mavacamten)

In Europe, following an opinion from the CHMP of the EMA, Camzyos received a label update to reduce the frequency of required echocardiography monitoring once a patient treated for obstructive hypertrophic cardiomyopathy is on a stable dose.

 

In addition, the company is today announcing the receipt of an April Prescription Drug User Fee Act (PDUFA) goal date from the FDA in the same setting.

Immunology

Category

Asset

Milestone

Clinical & Research

Sotyktu® (deucravacitinib)

Results from the Phase 3 POETYK PsA-1 and POETYK PsA-2 trials evaluating the efficacy and safety of Sotyktu in adults with active psoriatic arthritis (PsA) met their primary endpoint, with a significantly greater proportion of Sotyktu-treated patients achieving at least a 20 percent improvement in signs and symptoms of disease after 16 weeks of treatment compared with placebo.

 

In addition, both trials met secondary endpoints across PsA disease activity at Week 16. In both studies, Sotyktu was well-tolerated and demonstrated safety consistent with the established safety profile of Sotyktu observed in a Phase 2 PsA clinical trial and Phase 3 moderate-to-severe plaque psoriasis clinical trials.

FULL-YEAR FINANCIAL RESULTS

All comparisons are made versus the same period in 2023 unless otherwise stated.

  • Bristol Myers Squibb posted revenues of $48.3 billion, an increase of 7%, or 9% when adjusted for foreign exchange impacts, primarily driven by the Growth Portfolio and higher demand for Eliquis, partially offset by the impact of generics on Sprycel, Revlimid and Abraxane.

    • U.S. revenues increased 9%to$34.1 billion, primarily due to higher demand for the Growth Portfolio and Eliquis, partially offset by the impact of generics on Sprycel, Revlimid and Abraxane.

    • International revenues increased 3% to $14.2 billion, or 8.0% when adjusted for foreign exchange impacts, primarily due to demand for Growth Portfolio products, partially offset by the impact of generics within the Legacy Portfolio.

  • On a GAAP basis, gross margin decreased from 76.2% to 71.1%, primarily driven by intangible asset impairment charges and product mix. On a non-GAAP basis, gross margin decreased from 76.6% to 75.3%, primarily due to product mix.

  • On a GAAP and non-GAAP basis, marketing, selling and administrative expenses increased 8% to $8.4 billion and 4% to $8.0 billion, respectively. The increase is primarily due to the timing of spend and the impact of recent acquisitions.

  • On a GAAP basis, research and development expenses increased 20% to $11.2 billion, primarily due to the impact of recent acquisitions and IPRD impairment charges. On a non-GAAP basis, research and development expenses increased 7% to $9.8 billion, primarily due to the impact of recent acquisitions.

  • On a GAAP and non-GAAP basis, Acquired IPRD increased from $913 million to $13.4 billion driven by a one-time Acquired IPRD charge from the Karuna asset acquisition and SystImmune collaboration. On a GAAP and non-GAAP basis, licensing income was $122 million during the year compared to $142 million in 2023.

  • On a GAAP basis, amortization of acquired intangible assets decreased 2% to $8.9 billion, primarily due to lower amortization expense related to Revlimid, partially offset by the RayzeBio acquisition in 2024.

  • On a GAAP basis, income tax expense was $554 million despite a pre-tax loss of $8.4 billion, primarily due to a $12.1 billion non-tax deductible charge for the Karuna acquisition. The 2023 GAAP effective tax rate was impacted by a non-U.S. tax ruling on statutory impairment deductibility, changes in tax reserves, valuation allowances, and IRS guidance on non-U.S. R&D expense deductibility. On a non-GAAP basis, the effective tax rate increased from 14.7% to 56.8%, primarily due to the non-tax deductible charge.

  • The company reported on a GAAP basis net loss attributable to Bristol Myers Squibb of $8.9 billion, or $(4.41) per share, compared to earnings attributable to Bristol Myers Squibb of $8.0 billion, or $3.86 per share for the same period a year ago. On a non-GAAP basis the company reported net earnings attributable to Bristol Myers Squibb of $2.3 billion, or $1.15 per share, compared to earnings attributable to Bristol Myers Squibb of $15.6 billion, or $7.51 per share for the same period a year ago. In addition to the non-GAAP drivers noted above, non-GAAP EPS was impacted by higher interest expense.

FULL-YEAR PRODUCT REVENUE HIGHLIGHTS

 

($ amounts in millions)

 

Year Ended December

31, 2024

 

% Change from Year Ended

December 31, 2023

 

% Change from

Year Ended

December 31,

2023 Ex-F/X**

 

 

U.S.

 

Int’l(c)

 

WW(d)

 

U.S.

 

Int’l(c)

 

WW(d)

 

Int’l(c)

 

WW(d)

Growth Portfolio

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Opdivo

 

$

5,350

 

$

3,954

 

$

9,304

 

2%

 

5%

 

3%

 

14%

 

7%

Orencia

 

 

2,770

 

 

912

 

 

3,682

 

2%

 

2%

 

2%

 

10%

 

4%

Yervoy

 

 

1,599

 

 

931

 

 

2,530

 

16%

 

8%

 

13%

 

15%

 

16%

Reblozyl

 

 

1,444

 

 

329

 

 

1,773

 

80%

 

61%

 

76%

 

65%

 

77%

Opdualag

 

 

870

 

 

58

 

 

928

 

41%

 

>200%

 

48%

 

>200%

 

48%

Breyanzi

 

 

591

 

 

156

 

 

747

 

95%

 

156%

 

105%

 

162%

 

106%

Camzyos

 

 

543

 

 

59

 

 

602

 

141%

 

>200%

 

161%

 

>200%

 

161%

Zeposia

 

 

403

 

 

163

 

 

566

 

26%

 

42%

 

30%

 

42%

 

30%

Abecma

 

 

242

 

 

164

 

 

406

 

(32)%

 

44%

 

(14)%

 

47%

 

(13)%

Sotyktu

 

 

190

 

 

56

 

 

246

 

21%

 

>200%

 

45%

 

>200%

 

46%

Krazati

 

 

118

 

 

8

 

 

126

 

N/A

 

N/A

 

N/A

 

N/A

 

N/A

Augtyro

 

 

36

 

 

2

 

 

38

 

>200%

 

N/A

 

>200%

 

N/A

 

>200%

Cobenfy

 

 

10

 

 

 

 

10

 

N/A

 

N/A

 

N/A

 

N/A

 

N/A

Other Growth Products(a)

 

 

674

 

 

931

 

 

1,605

 

9%

 

58%

 

33%

 

61%

 

34%

Total Growth Portfolio

 

 

14,840

 

 

7,723

 

 

22,563

 

17%

 

16%

 

17%

 

24%

 

19%

Legacy Portfolio

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Eliquis

 

 

9,631

 

 

3,702

 

 

13,333

 

14%

 

(1)%

 

9%

 

—%

 

9%

Revlimid

 

 

4,999

 

 

774

 

 

5,773

 

(4)%

 

(14)%

 

(5)%

 

(11)%

 

(5)%

Pomalyst/Imnovid

 

 

2,695

 

 

850

 

 

3,545

 

15%

 

(23)%

 

3%

 

(22)%

 

3%

Sprycel

 

 

983

 

 

303

 

 

1,286

 

(31)%

 

(40)%

 

(33)%

 

(36)%

 

(32)%

Abraxane

 

 

541

 

 

334

 

 

875

 

(23)%

 

11%

 

(13)%

 

25%

 

(8)%

Other Legacy Products(b)

 

 

416

 

 

509

 

 

925

 

25%

 

(19)%

 

(4)%

 

(18)%

 

(3)%

Total Legacy Portfolio

 

 

19,265

 

 

6,472

 

 

25,737

 

4%

 

(10)%

 

—%

 

(8)%

 

1%

Total Revenues

 

$

34,105

 

$

14,195

 

$

48,300

 

9%

 

3%

 

7%

 

8%

 

9%

**

See “Use of Non-GAAP Financial Information”.

(a)

Includes Nulojix, Onureg, Inrebic, Empliciti and royalty revenue.

(b)

Includes other mature brands.

(c)

Beginning in 2024, Puerto Rico revenues are included in International revenues. Prior period amounts have been reclassified to conform to the current presentation.

(d)

Worldwide (WW) includes U.S. and International (Int’l).

FULL-YEAR PRODUCT REVENUE HIGHLIGHTS

Growth Portfolio

Growth Portfolio worldwide revenues increased to $22.6 billion compared to $19.4 billion in the prior year period, representing growth of 17% on a reported basis, or 19% when adjusted for foreign exchange impacts. Growth Portfolio revenues were primarily driven by higher demand for Reblozyl,Breyanzi, Camzyos and Opdualag.

Legacy Portfolio

Revenues for the Legacy Portfolio remained relatively flat at $25.7 billion compared to $25.6 billion in the prior year period, and increased 1% when adjusted for foreign exchange impacts. Legacy Portfolio revenues were primarily driven by higher demand for Eliquis, offset by the impact of generics on Sprycel,Revlimid, Abraxane and Pomalyst.

Update on Strategic Productivity Initiative

Bristol Myers Squibb is expanding its existing strategic productivity initiative to include approximately $2 billion in additional annualized cost savings by the end of 2027.

Under this expanded initiative, savings will be driven by changes in organizational design and efforts to enhance operational efficiency. These savings will be removed from our cost structure to contribute to a leaner, more efficient company while investing behind growth brands and promising areas of science.

Financial Guidance

Bristol Myers Squibb is providing key 2025 non-GAAP line-item guidance assumptions as outlined below.

We estimate total revenues to be approximately $45.5 billion, reflecting, as previously expected, the near-term impact of generics across Revlimid, Pomalyst, Sprycel and Abraxane, which we expect to result in a revenue decline of approximately 18-20% of the Legacy Portfolio. This is expected to be partially offset by the continued strength of our Growth Portfolio. This guidance also reflects an approximate $500 million expected negative impact to revenue due to foreign exchange.

2025 Non-GAAP1 Line-Item Guidance

Total Revenues

(Reported & Ex-F/X)

~$45.5 billion

Gross Margin %

~72%

Operating Expenses2

~$16 billion

Other Income/(Expense)

~$30 million

Tax Rate

~18%

Diluted EPS

$6.55-$6.85

1See “Use of Non-GAAP Financial Information.”

2Operating Expenses = MS&A and R&D, excluding Acquired IPRD and Amortization of acquired intangible assets.

The 2025 financial guidance excludes the impact of any potential future strategic acquisitions, divestitures, specified items that have not yet been identified and quantified, and the impact of future Acquired IPRD charges. To the extent we have quantified the impact of significant R&D charges or other income resulting from upfront or contingent milestone payments in connection with asset acquisitions or licensing of third-party intellectual property rights, we may update this information from time to time on our website www.bms.com, in the “Investors” section. Non-GAAP guidance assumes current exchange rates. The financial guidance is subject to risks and uncertainties applicable to all forward-looking statements as described elsewhere in this press release.

A reconciliation of forward-looking non-GAAP measures, including non-GAAP EPS, to the most directly comparable GAAP measures is not provided because comparable GAAP measures for such measures are not reasonably accessible or reliable due to the inherent difficulty in forecasting and quantifying measures that would be necessary for such reconciliation. Namely, we are not, without unreasonable effort, able to reliably predict the impact of accelerated depreciation and impairment charges, legal and other settlements, gains and losses from equity investments and other adjustments. In addition, the company believes such a reconciliation would imply a degree of precision and certainty that could be confusing to investors. These items are uncertain, depend on various factors and may have a material impact on our future GAAP results. See “Cautionary Statement Regarding Forward-Looking Statements” and “Use of Non-GAAP Financial Information.”

Conference Call Information

Bristol Myers Squibb will host a conference call today, Thursday, February 6, 2025, at 8:00 a.m. ET, during which company executives will review quarterly and annual financial results and address inquiries from investors and analysts. Investors and the general public are invited to listen to a live webcast of the call at http://investor.bms.com.

Investors and the public can register for the live conference call here. Those unable to register can access the live conference call by dialing in the U.S. toll-free 1-833-816-1116 or international +1 412-317-0705. Materials related to the call will be available at http://investor.bms.com prior to the start of the conference call.

A replay of the webcast will be available at http://investor.bms.com approximately three hours after the conference call concludes. A replay of the conference call will be available beginning at 11:30 a.m. ET on February 6, 2025, through 11:30 a.m. ET on February 20, 2025, by dialing in the U.S. toll free 1-877-344-7529 or international +1 412-317-0088, confirmation code: 5943651.

About Bristol Myers Squibb

Bristol Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. For more information about Bristol Myers Squibb, visit us at BMS.com or follow us on LinkedIn, X, YouTube, Facebook, and Instagram.

corporatefinancial-news

Use of Non-GAAP Financial Information

In discussing financial results and guidance, the company refers to financial measures that are not in accordance with U.S. Generally Accepted Accounting Principles (GAAP). The non-GAAP financial measures are provided as supplemental information to the financial measures presented in this press release that are calculated and presented in accordance with GAAP and are presented because management has evaluated the company’s financial results both including and excluding the adjusted items or the effects of foreign currency translation, as applicable, and believes that the non-GAAP financial measures presented portray the results of the company’s baseline performance, supplement or enhance management’s, analysts’ and investors’ overall understanding of the company’s underlying financial performance and trends and facilitate comparisons among current, past and future periods. In addition, non-GAAP gross margin, which is gross profit excluding certain specified items, as a percentage of revenues, non-GAAP operating margin, which is gross profit less marketing, selling and administrative expenses and research and development expenses excluding certain specified items as a percentage of revenues, non-GAAP operating expenses, which is marketing, selling and administrative and research and development expenses excluding certain specified items, non-GAAP marketing, selling and administrative expenses, which is marketing, selling and administrative expenses excluding certain specified items, and non-GAAP research and development expenses, which is research and development expenses excluding certain specified items, are relevant and useful for investors because they allow investors to view performance in a manner similar to the method used by our management and make it easier for investors, analysts and peers to compare our operating performance to other companies in our industry and to compare our year-over-year results.

This earnings release and the accompanying tables also provide certain revenues and expenses, as well as non-GAAP measures, excluding the impact of foreign exchange (“Ex-Fx”). We calculate foreign exchange impacts by converting our current-period local currency financial results using the prior period average currency rates and comparing these adjusted amounts to our current-period results. Ex-Fx financial measures are not accounted for according to GAAP because they remove the effects of currency movements from GAAP results.

Non-GAAP financial measures such as non-GAAP earnings and related EPS information are adjusted to exclude certain costs, expenses, gains and losses and other specified items that are evaluated on an individual basis after considering their quantitative and qualitative aspects and typically have one or more of the following characteristics, such as being highly variable, difficult to project, unusual in nature, significant to the results of a particular period or not indicative of past or future operating results. These items are excluded from non-GAAP earnings and related EPS information because the company believes they neither relate to the ordinary course of the company’s business nor reflect the company’s underlying business performance. Similar charges or gains were recognized in prior periods and will likely reoccur in future periods, including amortization of acquired intangible assets, including product rights that generate a significant portion of our ongoing revenue and will recur until the intangible assets are fully amortized, unwinding of inventory purchase price adjustments, acquisition and integration expenses, restructuring costs, accelerated depreciation and impairment of property, plant and equipment and intangible assets, costs of acquiring a priority review voucher, divestiture gains or losses, stock compensation resulting from acquisition-related equity awards, pension, legal and other contractual settlement charges, equity investment and contingent value rights fair value adjustments (including fair value adjustments attributed to limited partnership equity method investments), income resulting from the change in control of the Nimbus Therapeutics TYK2 Program and amortization of fair value adjustments of debt acquired from Celgene in our 2019 exchange offer, among other items. Deferred and current income taxes attributed to these items are also adjusted for considering their individual impact to the overall tax expense, deductibility and jurisdictional tax rates. Certain other significant tax items are also excluded such as the impact resulting from a non-U.S. tax ruling regarding the deductibility of a statutory impairment of subsidiary investments and release of income tax reserves relating to the Celgene acquisition.

Because the non-GAAP financial measures are not calculated in accordance with GAAP, they should not be considered superior to and are not intended to be considered in isolation or as a substitute for the related financial measures presented in the press release that are prepared in accordance with GAAP and may not be the same as or comparable to similarly titled measures presented by other companies due to possible differences in method and in the items being adjusted. We encourage investors to review our financial statements and publicly-filed reports in their entirety and not to rely on any single financial measure.

Reconciliations of the non-GAAP financial measures to the most comparable GAAP measures are provided in the accompanying financial tables and will also be available on the company’s website at www.bms.com. Within the accompanying financial tables presented, certain columns and rows may not add due to the use of rounded numbers. Percentages and EPS amounts presented are calculated from the underlying amounts.

A reconciliation of forward-looking non-GAAP measures, including non-GAAP EPS, to the most directly comparable GAAP measures is not provided because comparable GAAP measures for such measures are not reasonably accessible or reliable due to the inherent difficulty in forecasting and quantifying measures that would be necessary for such reconciliation. Namely, we are not, without unreasonable effort, able to reliably predict the impact of accelerated depreciation and impairment charges, legal and other settlements, gains and losses from equity investments and other adjustments. In addition, the company believes such a reconciliation would imply a degree of precision and certainty that could be confusing to investors. These items are uncertain, depend on various factors and may have a material impact on our future GAAP results.

Website Information

We routinely post important information for investors on our website, BMS.com, in the “Investors” section. We may use this website as a means of disclosing material, non-public information and for complying with our disclosure obligations under Regulation FD. Accordingly, investors should monitor the Investors section of our website, in addition to following our press releases, Securities and Exchange Commission (SEC) filings, public conference calls, presentations and webcasts. We may also use social media channels to communicate with our investors and the public about our company, our products and other matters, and those communications could be deemed to be material information. The information contained on, or that may be accessed through, our website or social media channels are not incorporated by reference into, and are not a part of, this document.

Cautionary Statement Regarding Forward-Looking Statements

This earnings release and the related attachments (as well as the oral statements made with respect to information contained in this release and the attachments) contain certain “forward-looking” statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, regarding, among other things, the company’s 2025 financial guidance, its Strategic Productivity Initiative, its business development and capital allocation strategy, anticipated developments in the company’s pipeline, expectations with respect to the company’s future market position and the projected benefits of the company’s alliances and other business development activities. These statements may be identified by the fact that they use words such as “should,” “could,” “expect,” “anticipate,” “estimate,” “target,” “may,” “project,” “guidance,” “intend,” “plan,” “believe,” “will” and other words and terms of similar meaning and expression in connection with any discussion of future operating or financial performance, although not all forward-looking statements contain such terms. All statements that are not statements of historical facts are, or may be deemed to be, forward-looking statements. No forward-looking statement can be guaranteed, and there is no assurance that the company will achieve its financial guidance and long-term targets, that the company’s future clinical studies will support the data described in this release, that the company’s product candidates will receive necessary clinical and manufacturing regulatory approvals, that the company’s pipeline products will prove to be commercially successful, that clinical and manufacturing regulatory approvals will be sought or obtained within currently expected timeframes, or that contractual milestones will be achieved.

Forward-looking statements are based on current expectations and projections about the company’s future financial results, goals, plans and objectives and involve inherent risks, assumptions and uncertainties, including internal or external factors that could delay, divert or change any of them in the next several years, that are difficult to predict, may be beyond the company’s control and could cause the company’s future financial results, goals, plans and objectives to differ materially from those expressed in, or implied by, the statements. Such risks, uncertainties and other matters include, but are not limited to: increasing pricing pressures from market access, pharmaceutical pricing controls and discounting; market actions taken by private and government payers to manage drug utilization and contain costs; the company’s ability to retain patent and market exclusivity for certain products; regulatory changes that result in lower prices, lower reimbursement rates and smaller populations for whom payers will reimburse; changes under the 340B Drug Pricing Program; the company’s ability to obtain and maintain regulatory approval for its product candidates; the possibility of difficulties and delays in product introduction and commercialization; increasing industry competition; potential difficulties, delays and disruptions in manufacturing, distribution or sale of products; the company’s ability to identify potential strategic acquisitions, licensing opportunities or other beneficial transactions; failure to complete, or delays in completing, collaborations, acquisitions, divestitures, alliances and other portfolio actions and the failure to achieve anticipated benefits from such transactions and actions; exposure to litigation and/or regulatory actions or investigations; the impact of any healthcare reform and legislation or regulatory action in the United States and international markets; increasing market penetration of lower-priced generic products; the failure of the company’s suppliers, vendors, outsourcing partners, alliance partners and other third parties to meet their contractual, regulatory and other obligations; the impact of counterfeit or unregistered versions of the company’s products and from stolen products; product label changes or other measures that could result in declining sales; safety or efficacy concerns regarding the company’s products or any product in the same class as the company’s products; the risk of cyber-attacks and unauthorized disclosure of trade secrets or other confidential data; the company’s ability to execute its financial, strategic and operational plans; the company’s ability to attract and retain key personnel; the impact of the company’s significant indebtedness; political and financial instability of international economies and sovereign risk; interest rate and currency exchange rate fluctuations, credit and foreign exchange risk management; risks relating to the use of social media platforms; issuance of new or revised accounting standards; and risks relating to public health outbreaks, epidemics and pandemics.

Forward-looking statements in this earnings release should be evaluated together with the many risks and uncertainties that affect the company’s business and market, particularly those identified in the cautionary statement and risk factors discussion in the company’s Annual Report on Form 10-K for the year ended December 31, 2023, as updated by the company’s subsequent Quarterly Reports on Form 10-Q, Current Reports on Form 8-K and other filings with the SEC. The forward-looking statements included in this document are made only as of the date of this document and except as otherwise required by applicable law, the company undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events, changed circumstances or otherwise.

BRISTOL-MYERS SQUIBB COMPANY

CONSOLIDATED STATEMENTS OF EARNINGS

(Unaudited, dollars and shares in millions except per share data)

 

 

Three Months Ended

December 31,

 

Twelve Months Ended

December 31,

 

2024

 

2023

 

2024

 

2023

 

 

 

 

 

 

 

 

Net product sales

$

11,811

 

 

$

11,168

 

 

$

46,778

 

 

$

43,778

 

Alliance and other revenues

 

531

 

 

 

309

 

 

 

1,522

 

 

 

1,228

 

Total Revenues

 

12,342

 

 

 

11,477

 

 

 

48,300

 

 

 

45,006

 

 

 

 

 

 

 

 

 

Cost of products sold(a)

 

4,812

 

 

 

2,745

 

 

 

13,968

 

 

 

10,693

 

Marketing, selling and administrative

 

2,136

 

 

 

2,073

 

 

 

8,414

 

 

 

7,772

 

Research and development

 

3,191

 

 

 

2,478

 

 

 

11,159

 

 

 

9,299

 

Acquired IPRD

 

30

 

 

 

600

 

 

 

13,373

 

 

 

913

 

Amortization of acquired intangible assets

 

1,693

 

 

 

2,278

 

 

 

8,872

 

 

 

9,047

 

Other (income)/expense, net

 

305

 

 

 

(371

)

 

 

893

 

 

 

(1,158

)

Total Expenses

 

12,167

 

 

 

9,803

 

 

 

56,679

 

 

 

36,566

 

 

 

 

 

 

 

 

 

(Loss)/Earnings Before Income Taxes

 

175

 

 

 

1,674

 

 

 

(8,379

)

 

 

8,440

 

Provision for Income Taxes

 

99

 

 

 

(88

)

 

 

554

 

 

 

400

 

Net (Loss)/Earnings

 

76

 

 

 

1,762

 

 

 

(8,933

)

 

 

8,040

 

Noncontrolling Interest

 

4

 

 

 

 

 

 

15

 

 

 

15

 

Net (Loss)/Earnings Attributable to BMS

$

72

 

 

$

1,762

 

 

$

(8,948

)

 

$

8,025

 

 

 

 

 

 

 

 

 

Weighted-Average Common Shares Outstanding:

 

 

 

 

 

 

 

Basic

 

2,029

 

 

 

2,027

 

 

 

2,027

 

 

 

2,069

 

Diluted

 

2,037

 

 

 

2,033

 

 

 

2,027

 

 

 

2,078

 

 

 

 

 

 

 

 

 

(Loss)/Earnings per Common Share:

 

 

 

 

 

 

 

Basic

$

0.04

 

 

$

0.87

 

 

$

(4.41

)

 

$

3.88

 

Diluted

 

0.04

 

 

 

0.87

 

 

 

(4.41

)

 

 

3.86

 

 

 

 

 

 

 

 

 

Other (income)/expense, net

 

 

 

 

 

 

 

Interest expense(b)

$

496

 

 

$

316

 

 

$

1,947

 

 

$

1,166

 

Royalty income – divestitures

 

(284

)

 

 

(239

)

 

 

(1,104

)

 

 

(862

)

Royalty and licensing income

 

(204

)

 

 

(420

)

 

 

(736

)

 

 

(1,488

)

Provision for restructuring

 

77

 

 

 

44

 

 

 

635

 

 

 

365

 

Investment income

 

(114

)

 

 

(145

)

 

 

(478

)

 

 

(449

)

Integration expenses

 

70

 

 

 

62

 

 

 

284

 

 

 

242

 

Litigation and other settlements

 

13

 

 

 

3

 

 

 

84

 

 

 

(390

)

Acquisition expense

 

 

 

 

32

 

 

 

50

 

 

 

32

 

Intangible asset impairments

 

 

 

 

 

 

 

47

 

 

 

29

 

Equity investment (gains)/losses

 

205

 

 

 

(53

)

 

 

(16

)

 

 

160

 

Divestiture losses

 

10

 

 

 

 

 

 

15

 

 

 

 

Other

 

36

 

 

 

29

 

 

 

165

 

 

 

37

 

Other (income)/expense, net

$

305

 

 

$

(371

)

 

$

893

 

 

$

(1,158

)

(a) Excludes amortization of acquired intangible assets.

(b) Includes amortization of purchase price adjustments to Celgene debt.

BRISTOL-MYERS SQUIBB COMPANY

PRODUCT REVENUES

FOR THE THREE MONTHS ENDED DECEMBER 31, 2024 AND 2023

(Unaudited, dollars in millions)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Change vs. 2023

 

 

2024

 

2023

 

GAAP

 

Excl. F/X**

 

 

U.S.

 

Int’l(c)

 

WW(d)

 

U.S.

 

Int’l(c)

 

WW(d)

 

U.S.

 

Int’l(c)

 

WW(d)

 

U.S.

 

Int’l(c)

 

WW(d)

Growth Portfolio

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Opdivo

 

$

1,423

 

$

1,056

 

$

2,479

 

$

1,401

 

$

986

 

$

2,387

 

2%

 

7%

 

4%

 

2%

 

15%

 

7%

Orencia

 

 

750

 

 

250

 

 

1,000

 

 

755

 

 

230

 

 

985

 

(1)%

 

9%

 

2%

 

(1)%

 

15%

 

3%

Yervoy

 

 

428

 

 

247

 

 

675

 

 

340

 

 

226

 

 

566

 

26%

 

9%

 

19%

 

26%

 

15%

 

22%

Reblozyl

 

 

445

 

 

102

 

 

547

 

 

270

 

 

50

 

 

320

 

65%

 

104%

 

71%

 

65%

 

110%

 

72%

Opdualag

 

 

233

 

 

21

 

 

254

 

 

186

 

 

4

 

 

190

 

25%

 

>200%

 

34%

 

25%

 

>200%

 

34%

Breyanzi

 

 

209

 

 

54

 

 

263

 

 

85

 

 

16

 

 

101

 

146%

 

>200%

 

160%

 

146%

 

>200%

 

162%

Camzyos

 

 

201

 

 

22

 

 

223

 

 

83

 

 

5

 

 

88

 

142%

 

>200%

 

153%

 

142%

 

>200%

 

153%

Zeposia

 

 

115

 

 

43

 

 

158

 

 

100

 

 

33

 

 

133

 

15%

 

30%

 

19%

 

15%

 

33%

 

20%

Abecma

 

 

59

 

 

46

 

 

105

 

 

56

 

 

44

 

 

100

 

5%

 

5%

 

5%

 

5%

 

5%

 

5%

Sotyktu

 

 

64

 

 

19

 

 

83

 

 

56

 

 

7

 

 

63

 

14%

 

171%

 

32%

 

14%

 

171%

 

32%

Krazati

 

 

36

 

 

3

 

 

39

 

 

 

 

 

 

 

N/A

 

N/A

 

N/A

 

N/A

 

N/A

 

N/A

Augtyro

 

 

13

 

 

2

 

 

15

 

 

1

 

 

 

 

1

 

>200%

 

N/A

 

>200%

 

>200%

 

N/A

 

>200%

Cobenfy

 

 

10

 

 

 

 

10

 

 

 

 

 

 

 

N/A

 

N/A

 

N/A

 

N/A

 

N/A

 

N/A

Other Growth Products(a)

 

 

186

 

 

326

 

 

512

 

 

165

 

 

160

 

 

325

 

13%

 

104%

 

58%

 

13%

 

106%

 

59%

Total Growth Portfolio

 

 

4,172

 

 

2,191

 

 

6,363

 

 

3,498

 

 

1,761

 

 

5,259

 

19%

 

24%

 

21%

 

19%

 

31%

 

23%

Legacy Portfolio

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Eliquis

 

 

2,221

 

 

974

 

 

3,195

 

 

1,872

 

 

1,002

 

 

2,874

 

19%

 

(3)%

 

11%

 

19%

 

(2)%

 

11%

Revlimid

 

 

1,169

 

 

170

 

 

1,339

 

 

1,244

 

 

206

 

 

1,450

 

(6)%

 

(17)%

 

(8)%

 

(6)%

 

(15)%

 

(7)%

Pomalyst/Imnovid

 

 

685

 

 

138

 

 

823

 

 

627

 

 

263

 

 

890

 

9%

 

(48)%

 

(8)%

 

9%

 

(47)%

 

(7)%

Sprycel

 

 

135

 

 

63

 

 

198

 

 

411

 

 

115

 

 

526

 

(67)%

 

(45)%

 

(62)%

 

(67)%

 

(41)%

 

(61)%

Abraxane

 

 

91

 

 

83

 

 

174

 

 

176

 

 

71

 

 

247

 

(48)%

 

17%

 

(30)%

 

(48)%

 

28%

 

(26)%

Other Legacy Products(b)

 

 

123

 

 

127

 

 

250

 

 

84

 

 

147

 

 

231

 

46%

 

(14)%

 

8%

 

46%

 

(15)%

 

7%

Total Legacy Portfolio

 

 

4,424

 

 

1,555

 

 

5,979

 

 

4,414

 

 

1,804

 

 

6,218

 

—%

 

(14)%

 

(4)%

 

—%

 

(12)%

 

(3)%

Total Revenues

 

$

8,596

 

$

3,746

 

$

12,342

 

$

7,912

 

$

3,565

 

$

11,477

 

9%

 

5%

 

8%

 

9%

 

9%

 

9%

**

See “Use of Non-GAAP Financial Information”.

(a)

Includes Onureg, Inrebic, Nulojix, Empliciti and royalty revenues.

(b)

Includes other mature brands.

(c)

Beginning in 2024, Puerto Rico revenues are included in International revenues. Prior period amounts have been reclassified to conform to the current presentation.

(d)

Worldwide (WW) includes U.S. and International (Int’l).

BRISTOL-MYERS SQUIBB COMPANY

PRODUCT REVENUES

FOR THE TWELVE MONTHS ENDED DECEMBER 31, 2024 AND 2023

(Unaudited, dollars in millions)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Change vs. 2023

 

 

2024

 

2023

 

GAAP

 

Excl. F/X**

 

 

U.S.

 

Int’l(c)

 

WW(d)

 

U.S.

 

Int’l(c)

 

WW(d)

 

U.S.

 

Int’l(c)

 

WW(d)

 

U.S.

 

Int’l(c)

 

WW(d)

Growth Portfolio

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Opdivo

 

$

5,350

 

$

3,954

 

$

9,304

 

$

5,246

 

$

3,763

 

$

9,009

 

2%

 

5%

 

3%

 

2%

 

14%

 

7%

Orencia

 

 

2,770

 

 

912

 

 

3,682

 

 

2,709

 

 

892

 

 

3,601

 

2%

 

2%

 

2%

 

2%

 

10%

 

4%

Yervoy

 

 

1,599

 

 

931

 

 

2,530

 

 

1,379

 

 

859

 

 

2,238

 

16%

 

8%

 

13%

 

16%

 

15%

 

16%

Reblozyl

 

 

1,444

 

 

329

 

 

1,773

 

 

804

 

 

204

 

 

1,008

 

80%

 

61%

 

76%

 

80%

 

65%

 

77%

Opdualag

 

 

870

 

 

58

 

 

928

 

 

615

 

 

12

 

 

627

 

41%

 

>200%

 

48%

 

41%

 

>200%

 

48%

Breyanzi

 

 

591

 

 

156

 

 

747

 

 

303

 

 

61

 

 

364

 

95%

 

156%

 

105%

 

95%

 

162%

 

106%

Camzyos

 

 

543

 

 

59

 

 

602

 

 

225

 

 

6

 

 

231

 

141%

 

>200%

 

161%

 

141%

 

>200%

 

161%

Zeposia

 

 

403

 

 

163

 

 

566

 

 

319

 

 

115

 

 

434

 

26%

 

42%

 

30%

 

26%

 

42%

 

30%

Abecma

 

 

242

 

 

164

 

 

406

 

 

358

 

 

114

 

 

472

 

(32)%

 

44%

 

(14)%

 

(32)%

 

47%

 

(13)%

Sotyktu

 

 

190

 

 

56

 

 

246

 

 

157

 

 

13

 

 

170

 

21%

 

>200%

 

45%

 

21%

 

>200%

 

46%

Krazati

 

 

118

 

 

8

 

 

126

 

 

 

 

 

 

 

N/A

 

N/A

 

N/A

 

N/A

 

N/A

 

N/A

Augtyro

 

 

36

 

 

2

 

 

38

 

 

1

 

 

 

 

1

 

>200%

 

N/A

 

>200%

 

>200%

 

N/A

 

>200%

Cobenfy

 

 

10

 

 

 

 

10

 

 

 

 

 

 

 

N/A

 

N/A

 

N/A

 

N/A

 

N/A

 

N/A

Other Growth Products(a)

 

 

674

 

 

931

 

 

1,605

 

 

620

 

 

591

 

 

1,211

 

9%

 

58%

 

33%

 

9%

 

61%

 

34%

Total Growth Portfolio

 

 

14,840

 

 

7,723

 

 

22,563

 

 

12,736

 

 

6,630

 

 

19,366

 

17%

 

16%

 

17%

 

17%

 

24%

 

19%

Legacy Portfolio

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Eliquis

 

 

9,631

 

 

3,702

 

 

13,333

 

 

8,482

 

 

3,724

 

 

12,206

 

14%

 

(1)%

 

9%

 

14%

 

—%

 

9%

Revlimid

 

 

4,999

 

 

774

 

 

5,773

 

 

5,195

 

 

902

 

 

6,097

 

(4)%

 

(14)%

 

(5)%

 

(4)%

 

(11)%

 

(5)%

Pomalyst/Imnovid

 

 

2,695

 

 

850

 

 

3,545

 

 

2,339

 

 

1,102

 

 

3,441

 

15%

 

(23)%

 

3%

 

15%

 

(22)%

 

3%

Sprycel

 

 

983

 

 

303

 

 

1,286

 

 

1,422

 

 

508

 

 

1,930

 

(31)%

 

(40)%

 

(33)%

 

(31)%

 

(36)%

 

(32)%

Abraxane

 

 

541

 

 

334

 

 

875

 

 

702

 

 

302

 

 

1,004

 

(23)%

 

11%

 

(13)%

 

(23)%

 

25%

 

(8)%

Other Legacy Products(b)

 

 

416

 

 

509

 

 

925

 

 

334

 

 

628

 

 

962

 

25%

 

(19)%

 

(4)%

 

25%

 

(18)%

 

(3)%

Total Legacy Portfolio

 

 

19,265

 

 

6,472

 

 

25,737

 

 

18,474

 

 

7,166

 

 

25,640

 

4%

 

(10)%

 

—%

 

4%

 

(8)%

 

1%

Total Revenues

 

$

34,105

 

$

14,195

 

$

48,300

 

$

31,210

 

$

13,796

 

$

45,006

 

9%

 

3%

 

7%

 

9%

 

8%

 

9%

**

See “Use of Non-GAAP Financial Information”.

(a)

Includes Onureg, Inrebic, Nulojix, Empliciti and royalty revenues.

(b)

Includes other mature brands.

(c)

Beginning in 2024, Puerto Rico revenues are included in International revenues. Prior period amounts have been reclassified to conform to the current presentation.

(d)

Worldwide (WW) includes U.S. and International (Int’l).

BRISTOL-MYERS SQUIBB COMPANY

INTERNATIONAL REVENUES(a)

FOREIGN EXCHANGE IMPACT (%)

(Unaudited)

 

 

Three Months Ended December 31, 2024

 

Twelve Months Ended December 31, 2024

 

Revenue

Change %

 

F/X %

Favorable/

(Unfavorable)

**

 

Revenue

Change %

Ex- F/X **

 

Revenue

Change %

 

F/X %

Favorable/

(Unfavorable)

**

 

Revenue

Change %

Ex- F/X **

Growth Portfolio

 

 

 

 

 

 

 

 

 

 

 

Opdivo

7%

 

(8)%

 

15%

 

5%

 

(9)%

 

14%

Orencia

9%

 

(6)%

 

15%

 

2%

 

(8)%

 

10%

Yervoy

9%

 

(6)%

 

15%

 

8%

 

(7)%

 

15%

Reblozyl

104%

 

(6)%

 

110%

 

61%

 

(4)%

 

65%

Opdualag

>200%

 

NM

 

>200%

 

>200%

 

NM

 

>200%

Breyanzi

>200%

 

NM

 

>200%

 

156%

 

(6)%

 

162%

Camzyos

>200%

 

NM

 

>200%

 

>200%

 

NM

 

>200%

Zeposia

30%

 

(3)%

 

33%

 

42%

 

—%

 

42%

Abecma

5%

 

—%

 

5%

 

44%

 

(3)%

 

47%

Sotyktu

171%

 

—%

 

171%

 

>200%

 

NM

 

>200%

Krazati

N/A

 

N/A

 

N/A

 

N/A

 

N/A

 

N/A

Augtyro

N/A

 

N/A

 

N/A

 

N/A

 

N/A

 

N/A

Cobenfy

N/A

 

N/A

 

N/A

 

N/A

 

N/A

 

N/A

Other Growth Products(b)

104%

 

(2)%

 

106%

 

58%

 

(3)%

 

61%

Total Growth Portfolio

24%

 

(7)%

 

31%

 

16%

 

(8)%

 

24%

Legacy Portfolio

 

 

 

 

 

 

 

 

 

 

 

Eliquis

(3)%

 

(1)%

 

(2)%

 

(1)%

 

(1)%

 

—%

Revlimid

(17)%

 

(2)%

 

(15)%

 

(14)%

 

(3)%

 

(11)%

Pomalyst/Imnovid

(48)%

 

(1)%

 

(47)%

 

(23)%

 

(1)%

 

(22)%

Sprycel

(45)%

 

(4)%

 

(41)%

 

(40)%

 

(4)%

 

(36)%

Abraxane

17%

 

(11)%

 

28%

 

11%

 

(14)%

 

25%

Other Legacy Products(c)

(14)%

 

1%

 

(15)%

 

(19)%

 

(1)%

 

(18)%

Total Legacy Portfolio

(14)%

 

(2)%

 

(12)%

 

(10)%

 

(2)%

 

(8)%

Total Revenues

5%

 

(4)%

 

9%

 

3%

 

(5)%

 

8%

NM

Not meaningful

**

See “Use of Non-GAAP Financial Information”.

(a)

Beginning in 2024, Puerto Rico revenues are included in International revenues. Prior period amounts have been reclassified to conform to the current presentation.

(b)

Includes Onureg, Nulojix, Empliciti and royalty revenues.

(c)

Includes other mature brands.

BRISTOL-MYERS SQUIBB COMPANY

WORLDWIDE REVENUES(a)

FOREIGN EXCHANGE IMPACT (%)

(Unaudited)

 

 

Three Months Ended December 31, 2024

 

Twelve Months Ended December 31, 2024

 

Revenue

Change %

 

F/X %

Favorable/

(Unfavorable)

**

 

Revenue

Change % Ex-

F/X **

 

Revenue

Change %

 

F/X %

Favorable/

(Unfavorable)

**

 

Revenue

Change % Ex-

F/X **

Growth Portfolio

 

 

 

 

 

 

 

 

 

 

 

Opdivo

4%

 

(3)%

 

7%

 

3%

 

(4)%

 

7%

Orencia

2%

 

(1)%

 

3%

 

2%

 

(2)%

 

4%

Yervoy

19%

 

(3)%

 

22%

 

13%

 

(3)%

 

16%

Reblozyl

71%

 

(1)%

 

72%

 

76%

 

(1)%

 

77%

Opdualag

34%

 

—%

 

34%

 

48%

 

—%

 

48%

Breyanzi

160%

 

(2)%

 

162%

 

105%

 

(1)%

 

106%

Camzyos

153%

 

—%

 

153%

 

161%

 

—%

 

161%

Zeposia

19%

 

(1)%

 

20%

 

30%

 

—%

 

30%

Abecma

5%

 

—%

 

5%

 

(14)%

 

(1)%

 

(13)%

Sotyktu

32%

 

—%

 

32%

 

45%

 

(1)%

 

46%

Krazati

N/A

 

N/A

 

N/A

 

N/A

 

N/A

 

N/A

Augtyro

>200%

 

NM

 

>200%

 

>200%

 

NM

 

>200%

Cobenfy

N/A

 

N/A

 

N/A

 

N/A

 

N/A

 

N/A

Other Growth Products(b)

58%

 

(1)%

 

59%

 

33%

 

(1)%

 

34%

Total Growth Portfolio

21%

 

(2)%

 

23%

 

17%

 

(2)%

 

19%

Legacy Portfolio

 

 

 

 

 

 

 

 

 

 

 

Eliquis

11%

 

—%

 

11%

 

9%

 

—%

 

9%

Revlimid

(8)%

 

(1)%

 

(7)%

 

(5)%

 

—%

 

(5)%

Pomalyst/Imnovid

(8)%

 

(1)%

 

(7)%

 

3%

 

—%

 

3%

Sprycel

(62)%

 

(1)%

 

(61)%

 

(33)%

 

(1)%

 

(32)%

Abraxane

(30)%

 

(4)%

 

(26)%

 

(13)%

 

(5)%

 

(8)%

Other Legacy Products(c)

8%

 

1%

 

7%

 

(4)%

 

(1)%

 

(3)%

Total Legacy Portfolio

(4)%

 

(1)%

 

(3)%

 

—%

 

(1)%

 

1%

Total Revenues

8%

 

(1)%

 

9%

 

7%

 

(2)%

 

9%

NM

Not meaningful

**

See “Use of Non-GAAP Financial Information”.

(a)

Worldwide (WW) includes U.S. and International (Int’l).

(b)

Includes Onureg, Nulojix, Empliciti and royalty revenues.

(c)

Includes other mature brands.

BRISTOL-MYERS SQUIBB COMPANY

RECONCILIATION OF GAAP AND NON-GAAP GROWTH DOLLARS AND PERCENTAGES EXCLUDING FOREIGN EXCHANGE IMPACT *

(Unaudited, dollars in millions)

 

THREE MONTHS

 

2024

 

2023

 

Change $

 

Change %

 

Favorable /

(Unfavorable)

F/X $ **

 

2024

Excl. F/X

**

 

Favorable /

(Unfavorable)

F/X % **

 

% Change

Excl. F/X

**

Revenues

 

$

12,342

 

 

$

11,477

 

 

$

865

 

 

8

%

 

$

(142)

 

$

12,484

 

(1)%

 

9%

Gross profit

 

 

7,530

 

 

 

8,732

 

 

 

(1,202

)

 

(14

)%

 

 

N/A

 

 

N/A

 

N/A

 

N/A

Gross profit excluding specified items(a)

 

 

9,130

 

 

 

8,770

 

 

 

360

 

 

4

%

 

 

N/A

 

 

N/A

 

N/A

 

N/A

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Gross margin(b)

 

 

61.0

%

 

 

76.1

%

 

 

 

 

 

 

 

 

 

 

 

 

Gross margin excluding specified items

 

 

74.0

%

 

 

76.4

%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Marketing, selling and administrative

 

 

2,136

 

 

 

2,073

 

 

 

63

 

 

3

%

 

 

21

 

 

2,157

 

1%

 

4%

Marketing, selling and administrative excluding specified items(a)

 

 

2,105

 

 

 

2,064

 

 

 

41

 

 

2

%

 

 

21

 

 

2,126

 

1%

 

3%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Research and development

 

 

3,191

 

 

 

2,478

 

 

 

713

 

 

29

%

 

 

8

 

 

3,199

 

—%

 

29%

Research and development excluding specified items(a)

 

 

2,788

 

 

 

2,476

 

 

 

312

 

 

13

%

 

 

8

 

 

2,796

 

—%

 

13%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Operating margin(c)

 

 

17.8

%

 

 

36.4

%

 

 

 

 

 

 

 

 

 

 

 

 

Operating margin excluding specified items

 

 

34.3

%

 

 

36.9

%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

TWELVE MONTHS

 

2024

 

2023

 

Change $

 

Change %

 

Favorable /

(Unfavorable) F/X $ **

 

2024

Excl. F/X **

 

Favorable / (Unfavorable) F/X % **

 

% Change Excl. F/X

**

Revenues

 

$

48,300

 

 

$

45,006

 

 

$

3,294

 

 

7

%

 

$

(654)

 

$

48,954

 

(2)%

 

9%

Gross profit

 

 

34,332

 

 

 

34,313

 

 

 

19

 

 

%

 

 

N/A

 

 

N/A

 

N/A

 

N/A

Gross profit excluding specified items(a)

 

 

36,351

 

 

 

34,488

 

 

 

1,863

 

 

5

%

 

 

N/A

 

 

N/A

 

N/A

 

N/A

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Gross margin(b)

 

 

71.1

%

 

 

76.2

%

 

 

 

 

 

 

 

 

 

 

 

 

Gross margin excluding specified items

 

 

75.3

%

 

 

76.6

%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Marketing, selling and administrative

 

 

8,414

 

 

 

7,772

 

 

 

642

 

 

8

%

 

 

89

 

 

8,503

 

1%

 

9%

Marketing, selling and administrative excluding specified items(a)

 

 

7,992

 

 

 

7,678

 

 

 

314

 

 

4

%

 

 

89

 

 

8,081

 

1%

 

5%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Research and development

 

 

11,159

 

 

 

9,299

 

 

 

1,860

 

 

20

%

 

 

40

 

 

11,199

 

—%

 

20%

Research and development excluding specified items(a)

 

 

9,782

 

 

 

9,112

 

 

 

670

 

 

7

%

 

 

40

 

 

9,822

 

1%

 

8%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Operating margin(c)

 

 

30.6

%

 

 

38.3

%

 

 

 

 

 

 

 

 

 

 

 

 

Operating margin excluding specified items

 

 

38.5

%

 

 

39.3

%

 

 

 

 

 

 

 

 

 

 

 

 

*

Foreign exchange impacts were derived by converting our current-period local currency financial results using the prior period average currency rates and comparing these adjusted amounts to our current-period results.

**

See “Use of Non-GAAP Financial Information”.

(a)

Refer to the Specified Items schedule below for further details.

(b)

Represents gross profit as a percentage of Revenues.

(c)

Operating margin represents gross profit less marketing, selling and administrative expenses and research and development expenses, as a percentage of Revenues.

BRISTOL-MYERS SQUIBB COMPANY

SPECIFIED ITEMS

(Unaudited, dollars in millions)

 

 

Three Months Ended

December 31,

 

Twelve Months

Ended December

31,

 

2024

 

2023

 

2024

 

2023

Inventory purchase price accounting adjustments

$

13

 

 

$

 

 

$

47

 

 

$

84

 

Intangible asset impairment

 

1,559

 

 

 

27

 

 

 

1,839

 

 

 

27

 

Site exit and other costs

 

28

 

 

 

11

 

 

 

133

 

 

 

64

 

Cost of products sold

 

1,600

 

 

 

38

 

 

 

2,019

 

 

 

175

 

 

 

 

 

 

 

 

 

Acquisition related charges(a)

 

 

 

 

 

 

 

372

 

 

 

 

Site exit and other costs

 

31

 

 

 

9

 

 

 

50

 

 

 

94

 

Marketing, selling and administrative

 

31

 

 

 

9

 

 

 

422

 

 

 

94

 

 

 

 

 

 

 

 

 

IPRD impairments

 

390

 

 

 

 

 

 

980

 

 

 

80

 

Priority review voucher

 

 

 

 

 

 

 

 

 

 

95

 

Acquisition related charges(a)

 

 

 

 

 

 

 

348

 

 

 

 

Site exit and other costs

 

13

 

 

 

2

 

 

 

49

 

 

 

12

 

Research and development

 

403

 

 

 

2

 

 

 

1,377

 

 

 

187

 

 

 

 

 

 

 

 

 

Amortization of acquired intangible assets

 

1,693

 

 

 

2,278

 

 

 

8,872

 

 

 

9,047

 

 

 

 

 

 

 

 

 

Interest expense(b)

 

(12

)

 

 

(13

)

 

 

(49

)

 

 

(52

)

Equity investment (gain)/losses

 

204

 

 

 

(54

)

 

 

(18

)

 

 

152

 

Acquisition expenses

 

 

 

 

32

 

 

 

50

 

 

 

32

 

Integration expenses

 

70

 

 

 

62

 

 

 

284

 

 

 

242

 

Divestiture losses

 

10

 

 

 

 

 

 

15

 

 

 

 

Litigation and other settlements

 

 

 

 

 

 

 

61

 

 

 

(397

)

Provision for restructuring

 

77

 

 

 

44

 

 

 

635

 

 

 

365

 

Intangible asset impairment

 

 

 

 

 

 

 

47

 

 

 

29

 

Other

 

9

 

 

 

 

 

 

120

 

 

 

(6

)

Other (income)/expense, net

 

358

 

 

 

71

 

 

 

1,145

 

 

 

365

 

 

 

 

 

 

 

 

 

Increase to Earnings before income taxes

 

4,085

 

 

 

2,398

 

 

 

13,835

 

 

 

9,868

 

 

 

 

 

 

 

 

 

Income taxes on items above

 

(749

)

 

 

(695

)

 

 

(2,045

)

 

 

(1,639

)

Income tax reserve releases

 

 

 

 

 

 

 

(502

)

 

 

 

Income taxes attributed to a non-U.S. tax ruling

 

 

 

 

 

 

 

 

 

 

(656

)

Income taxes

 

(749

)

 

 

(695

)

 

 

(2,547

)

 

 

(2,295

)

 

 

 

 

 

 

 

 

Increase to net earnings

$

3,336

 

 

$

1,703

 

 

$

11,288

 

 

$

7,573

 

(a)

Includes cash settlement of unvested stock awards, and other related costs incurred in connection with the recent acquisitions of Karuna, RayzeBio and Mirati.

(b)

Includes amortization of purchase price adjustments to Celgene debt.

 

BRISTOL-MYERS SQUIBB COMPANY

RECONCILIATION OF CERTAIN GAAP LINE ITEMS TO CERTAIN NON-GAAP LINE ITEMS

(Unaudited, dollars and shares in millions except per share data)

 

 

Three Months Ended December 31,

2024

 

Twelve Months Ended December 31,

2024

 

GAAP

 

Specified

Items(a)

 

Non-GAAP

 

GAAP

 

Specified

Items(a)

 

Non-GAAP

Gross profit

$

7,530

 

 

$

1,600

 

 

$

9,130

 

 

$

34,332

 

 

$

2,019

 

 

$

36,351

 

Marketing, selling and administrative

 

2,136

 

 

 

(31

)

 

 

2,105

 

 

 

8,414

 

 

 

(422

)

 

 

7,992

 

Research and development

 

3,191

 

 

 

(403

)

 

 

2,788

 

 

 

11,159

 

 

 

(1,377

)

 

 

9,782

 

Amortization of acquired intangible assets

 

1,693

 

 

 

(1,693

)

 

 

 

 

 

8,872

 

 

 

(8,872

)

 

 

 

Other (income)/expense, net

 

305

 

 

 

(358

)

 

 

(53

)

 

 

893

 

 

 

(1,145

)

 

 

(252

)

Earnings/(Loss) before income taxes

 

175

 

 

 

4,085

 

 

 

4,260

 

 

 

(8,379

)

 

 

13,835

 

 

 

5,456

 

Provision for income taxes

 

99

 

 

 

749

 

 

 

848

 

 

 

554

 

 

 

2,547

 

 

 

3,101

 

Net earnings/(loss) attributable to BMS used for diluted EPS calculation

$

72

 

 

$

3,336

 

 

$

3,408

 

 

$

(8,948

)

 

$

11,288

 

 

$

2,340

 

 

 

 

 

 

 

 

 

 

 

 

 

Weighted-average common shares outstanding—diluted

 

2,037

 

 

 

2,037

 

 

 

2,037

 

 

 

2,027

 

 

 

2,032

 

 

 

2,032

 

Diluted earnings/(loss) per share

$

0.04

 

 

$

1.63

 

 

$

1.67

 

 

$

(4.41

)

 

$

5.56

 

 

$

1.15

 

 

 

 

 

 

 

 

 

 

 

 

 

Effective tax rate

 

56.6

%

 

 

(36.7

)%

 

 

19.9

%

 

 

(6.6

)%

 

 

63.4

%

 

 

56.8

%

 

 

 

 

 

 

 

 

 

 

 

 

 

Three Months Ended December 31,

2023

 

Twelve Months Ended December 31,

2023

 

GAAP

 

Specified

Items(a)

 

Non-GAAP

 

GAAP

 

Specified

Items(a)

 

Non-GAAP

Gross profit

$

8,732

 

 

$

38

 

 

$

8,770

 

 

$

34,313

 

 

$

175

 

 

$

34,488

 

Marketing, selling and administrative

 

2,073

 

 

 

(9

)

 

 

2,064

 

 

 

7,772

 

 

 

(94

)

 

 

7,678

 

Research and development

 

2,478

 

 

 

(2

)

 

 

2,476

 

 

 

9,299

 

 

 

(187

)

 

 

9,112

 

Amortization of acquired intangible assets

 

2,278

 

 

 

(2,278

)

 

 

 

 

 

9,047

 

 

 

(9,047

)

 

 

 

Other (income)/expense, net

 

(371

)

 

 

(71

)

 

 

(442

)

 

 

(1,158

)

 

 

(365

)

 

 

(1,523

)

Earnings before income taxes

 

1,674

 

 

 

2,398

 

 

 

4,072

 

 

 

8,440

 

 

 

9,868

 

 

 

18,308

 

Provision for income taxes

 

(88

)

 

 

695

 

 

 

607

 

 

 

400

 

 

 

2,295

 

 

 

2,695

 

Net earnings attributable to BMS used for diluted EPS calculation

$

1,762

 

 

$

1,703

 

 

$

3,465

 

 

$

8,025

 

 

$

7,573

 

 

$

15,598

 

 

 

 

 

 

 

 

 

 

 

 

 

Weighted-average common shares outstanding—diluted

 

2,033

 

 

 

2,033

 

 

 

2,033

 

 

 

2,078

 

 

 

2,078

 

 

 

2,078

 

Diluted earnings per share

$

0.87

 

 

$

0.83

 

 

$

1.70

 

 

$

3.86

 

 

$

3.65

 

 

$

7.51

 

 

 

 

 

 

 

 

 

 

 

 

 

Effective tax rate

 

(5.3

)%

 

 

20.2

%

 

 

14.9

%

 

 

4.7

%

 

 

10.0

%

 

 

14.7

%

(a) Refer to the Specified Items schedule above for further details. Effective tax rate on the Specified Items represents the difference between the GAAP and Non-GAAP effective tax rate.

BRISTOL-MYERS SQUIBB COMPANY

NET DEBT CALCULATION

AS OF DECEMBER 31, 2024 AND DECEMBER 31, 2023

(Unaudited, dollars in millions)

 

 

 

 

 

December 31,

2024

 

December 31,

2023

 

 

 

 

Cash and cash equivalents

$

10,346

 

 

$

11,464

 

Marketable debt securities – current

 

513

 

 

 

816

 

Marketable debt securities – non-current

 

320

 

 

 

364

 

Cash, cash equivalents and marketable debt securities

$

11,179

 

 

$

12,644

 

Short-term debt obligations

 

(2,046

)

 

 

(3,119

)

Long-term debt

 

(47,603

)

 

 

(36,653

)

Net debt position

$

(38,470

)

 

$

(27,128

)

 

For more information, contact:

Media Relations: [email protected]

Investor Relations: [email protected]

KEYWORDS: New Jersey United States North America

INDUSTRY KEYWORDS: Science Neurology Biotechnology Research Pharmaceutical Oncology Health Clinical Trials

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