Cornerstone Building Brands Helps Build Affordable Housing during COVID-19

Cornerstone Building Brands Helps Build Affordable Housing during COVID-19

 

CARY, N.C.–(BUSINESS WIRE)–Cornerstone Building Brands, Inc. (NYSE: CNR), the largest manufacturer of exterior building products in North America, announces the extension of its Connecting Communities initiative, which helps build affordable housing with families during the COVID-19 pandemic.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20201112005910/en/

In addition to donating $275K in building products through its Home for Good project, Cornerstone Building Brands is asking the public to share its #ConnectingCommunities video on social media and the company will donate $25 per share* to Habitat for Humanity’s Homes, Communities, Hope + You campaign. (Photo: Business Wire)

In addition to donating $275K in building products through its Home for Good project, Cornerstone Building Brands is asking the public to share its #ConnectingCommunities video on social media and the company will donate $25 per share* to Habitat for Humanity’s Homes, Communities, Hope + You campaign. (Photo: Business Wire)

In addition to donating $275K in building products through its Home for Good project, Cornerstone Building Brands is asking the public to share its #ConnectingCommunities video on social media and the company will donate $25 per share* to Habitat for Humanity’s Homes, Communities, Hope + You campaign, a network-wide fundraising initiative that will support Habitat’s work in communities all across the United States and around the world.

“Giving back to communities where we live, work and play is core to Cornerstone Building Brands’ purpose, and throughout the COVID-19 pandemic, we’ve focused our efforts on continuing this support,” said James S. Metcalf, chairman & chief executive officer, Cornerstone Building Brands. “The Connecting Communities campaign builds on our long-standing, purpose-driven commitment to help address the need for affordable housing across North America – an issue only exacerbated by the economic impact of the pandemic.”

Even before COVID-19, more than 18 million U.S. households (one in six) were spending 50 percent or more of their income on housing, forgoing personal and economic stability that safe, decent and affordable housing provides. Now, due to the pandemic, there is an even greater burden on low-income households, given their concentration in at-risk jobs. Twelve million households have at least one contributing member working in an at-risk industry. It remains clear that homeownership matters, and not having access to this takes a toll on the health and wellness of families. Cost-burdened households with children spend on average $190 less on food and 70 percent less on healthcare compared to families living in affordable homes.i

“A stable home is incredibly important for a family’s health,” said Julie Laird Davis, vice president of corporate and cause marketing partnerships for Habitat for Humanity International. “When families are paying too much for their homes and have to forego basic necessities in order to make ends meet, they are put in the position of making difficult decisions on a daily basis. We’re thankful Cornerstone Building Brands has partnered with us in our efforts to build safe, affordable homeownership with more families.”

Through its Home for Good project, Cornerstone Building Brands has helped build more than 500 affordable homes since 2016 and aims to provide products for 100 additional homes by June 2021.

“Everyone can help,” said Metcalf. “Visit www.CornerstoneBuildingBrands.com/connecting-communities and share our video on social media using the hashtag #ConnectingCommunities. For every share, Cornerstone Building Brands will donate $25 to Habitat for Humanity.”*

ABOUT CORNERSTONE BUILDING BRANDS

Cornerstone Building Brands is the largest manufacturer of exterior building products for residential and low-rise non-residential buildings in North America. Headquartered in Cary, North Carolina, we serve residential and commercial customers across new construction and repair and remodel markets. As the #1 manufacturer of vinyl windows, vinyl siding, insulated metal panels, metal roofing and wall systems and metal accessories, Cornerstone Building Brands combines an expansive portfolio of strong brands and quality products with a broad multichannel distribution platform that includes approximately 20,000 employees at manufacturing, distribution and branch office locations throughout North America. For more information, visit us at www.cornerstonebuildingbrands.com.

_____________

i Habitat for Humanity

*Up to a maximum total donation of $50,000

 

Kaity Lloyd

G&S Business Communications

Tel: 919-770-2824

[email protected]

KEYWORDS: United States North America North Carolina

INDUSTRY KEYWORDS: Social Media Philanthropy Family Consumer Residential Building & Real Estate Other Manufacturing Construction & Property Fund Raising Steel Foundation Communications Other Philanthropy Manufacturing

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In addition to donating $275K in building products through its Home for Good project, Cornerstone Building Brands is asking the public to share its #ConnectingCommunities video on social media and the company will donate $25 per share* to Habitat for Humanity’s Homes, Communities, Hope + You campaign. (Photo: Business Wire)

ezCater® and JLL Provide Employee Meal Solution to Boost Employee Safety and Confidence about Returning to the Office

Relish by ezCater™ promotes employee safety through daily meal delivery from local restaurants to the office

PR Newswire

BOSTON, Nov. 12, 2020 /PRNewswire/ — ezCater, the world’s largest online catering marketplace, today announced a program with JLL Experience Management to make daily lunches available through Relish in JLL properties nationwide.

Companies face a new operational challenge during COVID: ensuring that employees have safe, convenient access to food every day. Employees who venture out face long waits for reduced-capacity elevators and crowded restaurants. Getting meals delivered through Relish reduces risk, increases operational efficiency, and makes employees feel more confident about returning safely to the workplace.

With Relish, individually packaged and labeled meals arrive in a single, contactless delivery at a designated place and time, so there is less traffic in and out of the office. A daily rotation of menus provides variety for employees and supports local restaurants. Companies choose which days they want meals delivered, and how much of the cost to cover.

“JLL strives to be the leader on showcasing safe and successful re-entry strategies, both in our own offices and for our clients,” said Tom Larance, Head of Experience Management at JLL. “Finding solutions that help realize that goal, from cleaning to food delivery, and everything in between, is a top priority as we help clients reimagine the future of work and the office.”

“Companies across the US are searching for ways to keep their people safe and confident,” said Diane Swint, ezCater’s Head of Marketplace. “One major challenge is reducing the traffic in and out of buildings at lunchtime. We’re thrilled to work with JLL on this great solution for their corporate tenants.”

Four percent of proceeds from every Relish order placed at a JLL property go to Feeding America® via CaterCares. CaterCares was created in 2016 to mobilize corporate America in the fight against hunger. CaterCares has provided over 1 million meals to Feeding America, the largest domestic hunger-relief organization in the U.S.

To learn more about safe, convenient access to meals for your team, visit www.ezcater.com/getrelish.

About ezCater
ezCater is the largest national marketplace for business catering with 75,000+ restaurants and caterers and 138+ million people served. ezCater provides companies of all sizes, anywhere in the country, with COVID-smart food solutions for work. Nationwide, restaurants and caterers use ezCater’s platform to grow and manage their catering business. For more information or to place a catering order, visit www.ezcater.com.

About JLL
JLL (NYSE: JLL) is a leading professional services firm that specializes in real estate and investment management. JLL shapes the future of real estate for a better world by using the most advanced technology to create rewarding opportunities, amazing spaces and sustainable real estate solutions for our clients, our people and our communities. JLL is a Fortune 500 company with annual revenue of $18.0 billion in 2019, operations in over 80 countries and a global workforce of over 92,000 as of September 30, 2020. JLL is the brand name, and a registered trademark, of Jones Lang LaSalle Incorporated. For further information, visit jll.com.

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SOURCE ezCater

Schwab Announces Patent Pending Data Analytics Algorithm

Schwab Announces Patent Pending Data Analytics Algorithm

New approach to using data to improve client experience underscores Schwab’s rapid digital innovation

SAN FRANCISCO–(BUSINESS WIRE)–
Charles Schwab has developed a patent-pending algorithm designed to improve client experience and make investing more accessible. The algorithm was developed by a team of data scientists within Schwab’s Digital Services organization, which is responsible for leading the firm’s work to explore, develop and rapidly deploy innovations in digital technology that help deliver modern, easy-to-use experiences for current and future clients.

Schwab’s proprietary algorithm analyzes billions of pieces of client data in order to detect clients’ intent and automatically adapt to client-led changes in behavior and Schwab-led changes in the user experience. This enables Schwab to understand what clients attempt to do online and identify opportunities to improve the client experience. The ability to detect the client’s intent in real-time now gives Schwab the ability to build more efficient and seamless client experiences.

These client behavior insights can also be used in other channels to serve clients faster and more personally, such as seamlessly connecting a call-in client to the right representative based upon what they have recently been researching online, saving the client time on the phone. Schwab expects to use the new algorithm to make a range of client activities more efficient. For example, if a client attempts to conduct a wire transfer online but then calls the Schwab service line, they can be immediately directed to the team that can help with that type of transaction by phone. Additionally, the algorithm surfaces the web pages and searches that are driving highest call volumes, enabling Schwab to pinpoint client roadblocks and make those experiences easier and more intuitive.

The patent-pending algorithm was developed by Schwab’s Data Analytics & Insights team led by Tony Cyriac, the firm’s new Chief Data & Analytics Officer who joined the firm in June 2020. Cyriac’s team is responsible for leveraging data, analytics, and research to drive growth and improve the client experience across all business units at Schwab.

In discussing the development of the new algorithm, Cyriac says, “We are proud of the focus and progress we are making to put data to work to improve our clients’ experiences and anticipate their needs. In order to serve our clients holistically across business lines and channels, we must analyze their journey in the same manner in which they live it: they experience Schwab as a single entity regardless of whether they are trading, opening a brokerage account or resetting a pin on their debit card. Our goal is to meet clients where they are and help them accomplish what they need to do as quickly and seamlessly as possible.”

Schwab Recognized for Excellence in Analytics

In addition, The International Institute for Analytics (IIA), the leading independent analytics and data science research and advisory firm, has awarded Schwab with the 2020 Award for Excellence in Analytics (ANNY) for Schwab’s cross-channel analytics initiative, which leverages this patent-pending algorithm. The award evaluates impact of a range of analytics projects based on outcomes, ambition, scale, skills, and insights, recognizing firms that bring clarity and precision to critical business decision-making.

About Charles Schwab

At Charles Schwab we believe in the power of investing to help individuals create a better tomorrow. We have a history of challenging the status quo in our industry, innovating in ways that benefit investors and the advisors and employers who serve them, and championing our clients’ goals with passion and integrity.

Disclosures:

Brokerage Products: Not FDIC Insured • No Bank Guarantee • May Lose Value

Through its operating subsidiaries, the company provides a full range of wealth management, securities brokerage, banking, asset management, custody, and financial advisory services to individual investors and independent investment advisors. Its broker-dealer subsidiaries and their affiliates offer a complete range of investment services and products including an extensive selection of mutual funds; financial planning and investment advice; retirement plan and equity compensation plan services; referrals to independent, fee-based investment advisors; and custodial, operational and trading support for independent, fee-based investment advisors through Schwab Advisor Services. Its primary banking subsidiary, Charles Schwab Bank, SSB (member FDIC and an Equal Housing Lender), provides banking and lending services and products. More information is available at www.aboutschwab.com. Follow us on Twitter, Facebook, YouTube and LinkedIn.

TD Ameritrade, Inc. and TD Ameritrade Clearing, Inc., members FINRA/SIPC, are separate but affiliated companies and subsidiaries of TD Ameritrade Holding Corporation. TD Ameritrade Holding Corporation is a wholly owned subsidiary of The Charles Schwab Corporation. TD Ameritrade is a trademark jointly owned by TD Ameritrade IP Company, Inc. and The Toronto-Dominion Bank.

(1120-03Z4)

Marianne Ahlmann

Charles Schwab

415-667-1115

[email protected]

KEYWORDS: United States North America California

INDUSTRY KEYWORDS: Professional Services Data Management Technology Finance Consulting Banking

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RangeForce Becomes Crest Approved Training Provider

Global solution for building highly skilled security teams incorporates CREST-accredited courses to help UK organizations build cyber resilience

MANASSAS, Va., Nov. 12, 2020 (GLOBE NEWSWIRE) — RangeForce, the premier provider of hands-on, cloud-based cybersecurity training and cyber range exercises for building continuous cyber skills training programs, today announced it has received approval as a CREST-accredited training provider.

CREST is the not-for-profit accreditation and certification body representing the technical information security industry. CREST provides internationally recognised accreditation for organisations and individuals providing penetration testing, cyber incident response, and threat intelligence services.

“We are pleased to have achieved CREST criteria and membership requisites to be accepted as a CREST Approved Training Provider,” said RangeForce CEO Taavi Must. “Achieving CREST accreditation for our growing portfolio of training modules reflects the immense value of our unique approach to helping UK companies and the public sector prevent cyber-attacks through continuous, hands-on cyberskills development and blue team training.”

As a CREST approved training provider, our hundreds of training modules focused on security operations, threat hunting, network security, reverse engineering, red team, and blue team training are deemed acceptable to help cybersecurity professionals prepare for their CREST Practitioner Security Analyst (CPSA) and CREST Registered Penetration Tester (CRT) exams.

For more information on our extensive training courses and exercises, visit RangeForce

About RangeForce


RangeForce
makes creating highly skilled cybersecurity defenders simple, flexible, and fast for all enterprises. Powered by the industry’s first SaaS-based, integrated cybersecurity simulation and virtual cyber range, we help customers operationalize a security training program in hours, saving up to 65% over traditional training and up to $1M annually on hosted cyber ranges. RangeForce is revolutionizing cybersecurity training with its adaptive learning to rapidly train and cross-train DevOps, IT, and security professionals, and security training orchestration integrating best-of-breed solutions from a growing ecosystem of RangeForce partners. Train with us to build cyber resilience!

Contact:
Betsy Kosheff
[email protected]
413-717-1410

Lilly to Participate in Wolfe Research Virtual Healthcare Conference

PR Newswire

INDIANAPOLIS, Nov. 12, 2020 /PRNewswire/ — Eli Lilly and Company (NYSE:LLY) will participate in the Wolfe Research Virtual Healthcare Conference on Wednesday, November 18, 2020. Joshua Smiley, senior vice president and Lilly’s chief financial officer, will participate in a virtual fireside chat at 1:30 p.m., Eastern Time.

A live audio webcast will be available on the “Webcasts & Presentations” section of Lilly’s Investor website at https://investor.lilly.com/webcasts-and-presentations. A replay of the presentation will be available on this same website for approximately 90 days.

About Eli Lilly and Company
Lilly is a global healthcare leader that unites caring with discovery to create medicines that make life better for people around the world. We were founded more than a century ago by a man committed to creating high-quality medicines that meet real needs, and today we remain true to that mission in all our work. Across the globe, Lilly employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to communities through philanthropy and volunteerism. To learn more about Lilly, please visit us at www.lilly.com.  F-LLY   

Refer to:

Mark Taylor; [email protected]; (317) 276-5795 (Media)
Kevin Hern; [email protected]; (317) 277-1838 (Investors)

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SOURCE Eli Lilly and Company

ECS Announces Strategic Partnership with ISM, a ServiceNow Elite Partner

ECS Announces Strategic Partnership with ISM, a ServiceNow Elite Partner

Companies will leverage the ServiceNow platform to provide connected operations and IT management and operations solutions to help companies succeed in the post-COVID digital landscape

FAIRFAX, Va.–(BUSINESS WIRE)–ECS, a leading provider of advanced technology, science, and engineering solutions announced a partnership with Integrated Solutions Management (ISM), a business transformation accelerator that works with large organizations to drive successful Internet of Things (IoT) and IT strategies. ISM is a ServiceNow Elite Sales, Service, and Technology Partner, as well as the first Connected Operations North America Service Partner.

ECS is an award-winning IT solutions provider with over 20 years’ experience helping large enterprise organizations pursue IT modernization and digital transformation strategies. The company currently manages IT engineering and IoT security aboard the naval ship USNS Mercy, which was recently deployed to provide civilian care amid the COVID-19 pandemic in Los Angeles. ECS has also designed, deployed, and continues to manage major digital transformation strategies for government agencies, global hospitality companies, and other large enterprises with distributed operations. Recent and current engagements include service desk transformation, maintenance and technical support development, and human capital management for large federal customers.

ISM brings industry-leading expertise with IoT technology and IT service and operations management. Over the past seven years, ISM has deployed many of the most noteworthy ServiceNow deployments across the public and private sectors, including defense, healthcare, national laboratories, transportation, finance, manufacturing and managed service providers. In 2019, they launched a ServiceNow pilot program with transportation company TAPCO, using IoT data to manage and improve systems operations, field services, customer support, and asset management.

Together, ECS and ISM will help large organizations leverage the ServiceNow platform and IoT capabilities to achieve new efficiencies, manage critical infrastructure and devices, and optimize operations in the post-COVID digital landscape.Additional bundled solutions focus on asset management, IT operations (continuity of infrastructure provisioning), and security operations designed to meet enterprise needs for remote workforce capabilities and cloud-based operations.

“IoT represents a new frontier for government and industry alike,” said Martin Burke, president of ISM. “With ECS’ experience, scale, and program-level expertise, this partnership will allow us to bring ISM’s IoT and ServiceNow offerings to new customers across the government and commercial sectors.”

“We are thrilled to partner with ISM,” said George Wilson, president of ECS. “From human capital and asset management to cloud development and SecOps, this partnership will empower companies to succeed with powerful IoT and ServiceNow tools.”

About ECS

ECS, a segment of ASGN, delivers advanced solutions in cloud, cybersecurity, artificial intelligence (AI), machine learning (ML), application and IT modernization, science, and engineering. The company solves critical, complex challenges for customers across the U.S. public sector, defense, intelligence, and commercial industries. ECS maintains partnerships with leading cloud, cybersecurity, and AI/ML providers and holds specialized certifications in their technologies. Headquartered in Fairfax, Virginia, ECS has more than 3,000 employees throughout the United States. For more information, visit ECStech.com.

About ISM

Integrated Solutions Management (ISM) is a business transformation accelerator for commercial enterprises and public agencies. As a ServiceNow Elite Sales, Services, and Technology partner, we help organizations move beyond yesterday’s workflows and silos towards digital enterprises that are more efficient, responsive, and ready for tomorrow. We do this by using FRITZ®, a business transformation methodology that combines sector and function-area fluency with the ServiceNow platform’s capabilities to create new ways of solving your challenges, expanding your opportunities, and raising your sights. For more information, visit ism4it.com

About ASGN

ASGN Incorporated (NYSE: ASGN) is one of the foremost providers of IT and professional services in the technology, digital, creative, engineering, and life sciences fields across commercial and government sectors. Operating through its Apex, Oxford, and ECS segments, ASGN helps leading corporate enterprises and government organizations develop, implement, and operate critical IT and business solutions through its integrated offering of professional staffing and IT solutions. Our mission is to be the most trusted partner for companies seeking highly skilled human capital and integrated solutions to fulfill their strategic and operational needs. For more information, visit us at asgn.com.

John Heneghan, ECS Senior Vice President of Enterprise Solutions

301-518-6990

[email protected]

Martin Burke, ISM President and Chief Risk Officer

703-930-9481

[email protected]

KEYWORDS: United States North America Virginia

INDUSTRY KEYWORDS: Technology Contracts Consulting Security Other Technology Professional Services Internet Data Management Defense

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SHAREHOLDER ALERT: Rigrodsky & Long, P.A. Announces Investigation of Emisphere Technologies, Inc. Buyout

WILMINGTON, Del., Nov. 12, 2020 (GLOBE NEWSWIRE) — Rigrodsky & Long, P.A. announces that it is investigating Emisphere Technologies, Inc. (“Emisphere”) (OTC: EMIS) regarding possible breaches of fiduciary duties and other violations of law related to Emisphere’s agreement to be acquired by Novo Nordisk A/S (“Novo”) (NYSE: NVO) for approximately $1.34 billion in cash. Under the terms of the agreement, Emisphere’s shareholders will receive approximately $7.82 in cash per share.

To learn more about this investigation and your rights, visit: https://www.rl-legal.com/cases-emisphere-technologies-inc.

You may contact Seth D. Rigrodsky or Gina M. Serra cost and obligation free at (888) 969-4242 or [email protected].

Rigrodsky & Long, P.A., with offices in Delaware and New York, has recovered hundreds of millions of dollars on behalf of investors and achieved substantial corporate governance reforms in securities fraud and corporate class actions nationwide.

Attorney advertising.  Prior results do not guarantee a similar outcome.

CONTACT:         

Rigrodsky & Long, P.A.
Seth D. Rigrodsky
Gina M. Serra
(888) 969-4242 (Toll Free)
(302) 295-5310
Fax: (302) 654-7530
[email protected]
https://rl-legal.com

Lilly to Participate in Bernstein Operational Decisions Conference

PR Newswire

INDIANAPOLIS, Nov. 12, 2020 /PRNewswire/ — Eli Lilly and Company (NYSE:LLY) will participate in the Bernstein Operational Decisions Conference on Monday, November 16, 2020. Andrew Adams, Ph.D., vice president of new therapeutic modalities and scientific leader for Lilly’s anti-COVID-19 platform, Jeff Emmick, M.D., Ph.D., vice president of diabetes product development, and Mark Mintun, M.D., vice president of pain and neurodegeneration research and president of Avid Radiopharmaceuticals, will participate in a virtual fireside chat at 11:00 a.m., Eastern Time.

A live audio webcast will be available on the “Webcasts & Presentations” section of Lilly’s Investor website at https://investor.lilly.com/webcasts-and-presentations. A replay of the presentation will be available on this same website for approximately 90 days.

About Eli Lilly and Company
Lilly is a global healthcare leader that unites caring with discovery to create medicines that make life better for people around the world. We were founded more than a century ago by a man committed to creating high-quality medicines that meet real needs, and today we remain true to that mission in all our work. Across the globe, Lilly employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to communities through philanthropy and volunteerism. To learn more about Lilly, please visit us at www.lilly.com.  F-LLY   

Refer to: 
Mark Taylor; [email protected]; (317) 276-5795 (Media)
Kevin Hern; [email protected]; (317) 277-1838 (Investors)

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SOURCE Eli Lilly and Company

DEINOVE selected for a presentation at the C Diff Foundation annual Conference 2020

DEINOVE selected for a presentation at the C Diff Foundation annual Conference 2020

      ·Yannick Pletan to present the DNV3837 mechanism of action, key features of the antibiotic candidate and the protocol of the ongoing Phase II Clinical Trial in Clostridioides difficile infection

             

DEINOVE (Euronext Growth Paris: ALDEI), a French biotech company, pioneer in the exploration and exploitation of bacterial biodiversity to address the urgent, global challenge of antibiotic resistance and the need for next-generation active ingredients in the service of healthcare, announces a presentation at the C.diff foundation 8th annual Virtual Conference.

Yannick Pletan, MD, MSc, HEC, Chief Medical Officer and member of the board of directors of DEINOVE will present in the “Research In Progress” virtual poster session “A Phase 2 Clinical Trial Evaluating a Novel Antibiotic Against a Clostridium difficile Infection”. He will be presenting the results of the Phase I, the protocol of the ongoing multicenter Phase II in the United States, the clinical sites, the team and the key advantages of DNV3837 antibiotic candidate: intravenous administration, precise targeting at the infection site, ability to eliminate Clostridioides bacteria without affecting the gut microbiota.

Patients enrollment is ongoing in this Phase II trial despite a disrupted context due to the COVID-19 outbreak. Preliminary results of Part I of the study are expected by S1 2021.

Video presentation is online https://youtu.be/pShknVl5kDk

ABOUT CLOSTRIDIOIDES DIFFICILE INFECTIONS (CDI)

40% of patients suffering a Clostridioides difficile infection (CDI) have severe forms, associated with high morbidity and mortality rates. Over the past 20 years, CDIs tended to increase significantly in incidence and severity, particularly due to the development of new hypervirulent strains and the high risk of recurrence. The US Center for Disease Control and Prevention (CDC) recently identified CDIs as one of the leading causes of healthcare-associated infections before Staphylococcus aureus (MRSA1) infections. In 2017, in the United States, there were an estimated 223,900 cases in hospitalized patients and 12,800 deaths2. This disease does not affect the United States only, recent studies3 show that the incidence of this type of infection is vastly underestimated in other parts of the world such as Europe and Asia.

To date, there are no therapeutic solutions for patients with severe gastrointestinal infections. Since the oral route is compromised, the available treatments, which are mostly oral treatments, struggle to reach the intestine because of the patient’s pathological condition (reduced gastrointestinal motility, intubation, intestinal perforation, etc.), and the few antibiotics that could be administered intravenously (IV), do not cross the gastrointestinal barrier and therefore do not reach the site of infection.

ABOUT THE DNV3837 ANTIBIOTIC CANDIDATE

DNV3837 – a prodrug4 of the DNV3681 molecule (also known as MCB3681) – is a narrow-spectrum, hybrid oxazolidinone-quinolone synthetic antibiotic targeting only Gram-positive bacteria. It is developed as a highly active 1st line treatment targeting Clostridioides difficile.

It has demonstrated significant activity and superiority to reference treatments against isolates of C. difficile, regardless of their virulence (including the hyper virulent BI/NAP1/027 strain).

DNV3837 is an intravenous antibiotic that, when converted to its active form DNV3681, crosses the gastrointestinal barrier and accumulates in the intestinal lumen, allowing it to precisely target the infection site. Several Phase I trials (on approx. a hundred healthy volunteers) have shown a high concentration of the antibiotic in stools, a strong marker of its presence in the intestine. It has also demonstrated its ability to eliminate Clostridioides bacteria without affecting the gut microbiota. It has also shown an acceptable safety and tolerability profile.

FDA granted the DNV3837 drug with Qualified Infectious Disease Product (QIDP) designation and Fast Track status.

ABOUT THE PHASE II CLINICAL TRIAL TESTING DNV3837 IN CDI

The antibiotic candidate DNV3837 has been in a Phase II trial since the end of January 2020. The purpose of this trial is to evaluate its efficacy in CDI (through monitoring of symptoms, stool analysis, etc.), as well as to consolidate the safety and pharmacokinetic data in patients.

This trial is taking place in the United States in two stages:

  • In the first part, a cohort of 10 patients with moderate to severe CDI is treated with DNV3837. At the end of this part, the DSMB5  has scheduled to review the interim results.
  • The second part involves 30 patients with severe CDI. This is an open-label randomized trial testing DNV3837 (in 2/3 of patients) against an approved standard of care6 (1/3 of patients) for comparison purposes.

ABOUT DEINOVE

DEINOVE is a French biotech company, a pioneer in the exploitation of the unknown or little-known part of biodiversity.  By using rare or “non-cultivable” bacteria and by working on unexplored molecular pathways, the Company discovers, develops and produces antimicrobials to meet the urgent, global challenge of antibiotic resistance, and the need for next-generation active ingredients to serve Health.

In nearly 15 years, the Company has built a unique collection of over 10,000 bacterial strains and has developed a fully integrated technological platform that brings together the best of biological culture, synthetic biology and micro-biotechnology.

Today, DEINOVE has several development programs underway, including the antibiotic candidate   DNV3837, in a Phase II clinical trial in severe gastrointestinal infections with Clostridioides difficile, a real therapeutic challenge. Through its other program AGIR (Antibiotics against Resistant Infectious Germs), supported by Bpifrance, it is also continuing its exploration of biodiversity to supply its portfolio with new molecules. It relies on its own biodiversity and on the one entrusted to it by other specialists in the field.

DEINOVE has also developed and brought to market four particularly innovative active ingredients: a first which is phytoene-based and a neurosporene concentrate produced by Deinococcus geothermalis, as well as two cell extracts developed in collaboration.

DEINOVE, located in the Euromédecine science park in Montpellier, employs 56 people, mainly researchers, engineers and technicians, and has filed over 350 patent applications internationally. It is listed on EURONEXT GROWTH® (ALDEI – code ISIN FR0010879056).

CONTACTS

Investors
Mario Alcaraz
Chief Financial and Administrative Officer
Phone: +33 (0)4 48 19 01 00
[email protected]

 

Media
ALIZE RP – Caroline Carmagnol
Phone: +33 (0)6 64 18 99 59
[email protected]

 

 


1 MRSA: meticillin-resistant Staphylococcus aureus

2 https://www.cdc.gov/drugresistance/biggest-threats.html#cdiff

3 Balsells E, Shi T, Leese C, Lyell I, Burrows J, Wiuff C, Campbell H, Kyaw MH, and Nair H (2019) Global burden of Clostridium difficile infections: a systematic review and meta-analysis. J Glob Health 9:010407

4 Prodrug: substance whose transformation in the body results in an active product

5 DSMB – Data Safety Monitoring Board: a group of independent experts tasked to review the data generated during the trial and make recommendations on patient safety as well as trial relevance and validity.

6 Standard treatments approved in the United States for the treatment of CDIs include vancomycin, fidaxomicin and metronidazole (all three antibiotics). The choice will be at the discretion of the clinicians. 

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MiX Telematics To Host Nov 17 Webinar with Heavy Duty Trucking: 7 Steps To Get Started Monitoring and Modifying Driver Behavior

BOCA RATON, Fla., Nov. 12, 2020 (GLOBE NEWSWIRE) — MiX Telematics (NYSE: MIXT; JSE: MIX), a leading global SaaS provider of connected fleet management solutions, announced today that it will present a webinar titled, “7 Steps To Get Started Monitoring and Modifying Driver Behavior.” The event, hosted by Heavy Duty Trucking magazine, will take place Nov 17, 2020 at 2pm ET.

According to the FMCSA, in 2017 (latest figures available), 4,889 large trucks and buses were involved in fatal crashes, a 9 percent increase from 2016. The critical pre-crash event for 73 percent of the large trucks in fatal crashes was another vehicle, person, animal, or object in the large truck’s lane or encroaching into it.

While truck drivers were not always at fault in these crashes, driver behavior certainly plays a role. Behaviors such as speeding and tailgating often contribute to crashes, or to a driver’s ability to avoid a crash even when he/she isn’t responsible for the pre-crash event.

In this event, we’ll discuss how to get started monitoring and modifying driver behavior through telematics. Attendees will learn:

  • How ELDs already provide fleets with most of the data they need to begin
  • Key steps to take before you start a program
  • Best practices for sharing data with drivers
  • How to use pulse learning to keep safe driving skills fresh

To register for this free event, visit https://event.webcasts.com/starthere.jsp?ei=1382687&Sti=Webinars.

About MiX Telematics

MiX Telematics is a leading global provider of fleet and mobile asset management solutions, delivered as SaaS, to more than more than three quarters of a million subscribers in over 120 countries. In the U.S., MiX Telematics offers a broad range of solutions; from self-service telematics software that runs on any mobile device to enterprise solutions that are ELD compliant and include dedicated account managers who proactively monitor to ensure that customers achieve optimal value for their investment. The company provides solutions for efficiency, safety, compliance and security to fleets of all sizes. MiX Telematics was founded in 1996 and has offices in the United States, South Africa, the United Kingdom, Uganda, Brazil, Mexico, Australia and the United Arab Emirates as well as a network of more than 130 fleet partners worldwide. MiX Telematics shares are publicly traded on the New York Stock Exchange (NYSE: MIXT) and the Johannesburg Stock Exchange (JSE: MIX). For more information, visit www.mixtelematics.com

For further information:

Michelle Faulkner
Big Swing Communications
+1 617-510-6998
[email protected]